Evidence map›Paper›PMID 41760904›Full record

ArticleNature immunology2026

Reciprocal regulation of fibroblast-macrophage equilibrium governs skin integrity.

Apple Cortez Vollmers, Sunny Z Wu, Anthony Altieri, Erika E McCartney, Hannah Bender, Christopher D Davidson, Wyne P Lee, Juan Zhang, Crystal Hu, Surinder Jeet and 21 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
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  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Apple Cortez Vollmers *Genentech, South San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-2787-0797
Sunny Z Wu *Genentech, South San Francisco, CA, USA.
Anthony Altieri *Department of Immunology, University of Toronto, Toronto, Ontario, Canada.
Erika E McCartneyDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada.
Hannah BenderGenentech, South San Francisco, CA, USA.
Christopher D DavidsonGenentech, South San Francisco, CA, USA.
Wyne P LeeGenentech, South San Francisco, CA, USA.
Juan ZhangGenentech, South San Francisco, CA, USA.
Crystal HuGenentech, South San Francisco, CA, USA.
Surinder JeetGenentech, South San Francisco, CA, USA.
Ben HallGenentech, South San Francisco, CA, USA.
Ricardo A Irizarry-CaroGenentech, South San Francisco, CA, USA.
Alberto GuarnieriGenentech, South San Francisco, CA, USA.
Endi K SantosaGenentech, South San Francisco, CA, USA.
Jessica PrestonGenentech, South San Francisco, CA, USA.
Salil UttarwarGenentech, South San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-9690-7747
Jason A Vander HeidenGenentech, South San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-1474-310X
Yein ChungDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada.
Willie OrtizGenentech, South San Francisco, CA, USA.
Michael LongGenentech, South San Francisco, CA, USA.
Raymond AsuncionGenentech, South San Francisco, CA, USA.
Yeqing Angela YangGenentech, South San Francisco, CA, USA.
Jean X JiangThe University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.ORCID http://orcid.org/0000-0002-2185-5716
Zora ModrusanGenentech, South San Francisco, CA, USA.
Subba ChintalacharuvuGenentech, South San Francisco, CA, USA.
Christine MoussionGenentech, South San Francisco, CA, USA.
Akshay T KrishnamurtyGenentech, South San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-5382-1417
Wenxian FuGenentech, South San Francisco, CA, USA.
Sören MüllerGenentech, South San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-9490-5270
Matthew B BuechlerDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada. matthew.buechler@utoronto.ca.ORCID http://orcid.org/0000-0003-1902-622X
Shannon J TurleyGenentech, South San Francisco, CA, USA. shannon.turley@gmail.com.ORCID http://orcid.org/0000-0002-0444-3031

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fibroblast-macrophage crosstalk is well-established in vitro, and fibroblast-derived colony-stimulating factor 1 (CSF1) supports macrophages in select tissues. However, whether macrophages regulate fibroblasts in vivo remains unknown. Leveraging genetic mouse models, single-cell multi-omics, flow cytometry and imaging, we show that fibroblast depletion or loss of fibroblast-derived growth factors impacts skin macrophage populations in the dermis and hypodermis. Conditional deletion of Csf1 in Dpt

Indexed as

FibroblastsMacrophagesScleroderma, SystemicSkinAnimalsFemaleHumansMacrophage Colony-Stimulating FactorMiceMice, KnockoutReceptors, Granulocyte-Macrophage Colony-Stimulating FactorSignal TransductionWound HealingCSF1 protein, mouseCsf1r protein, mouseMacrophage Colony-Stimulating FactorReceptors, Granulocyte-Macrophage Colony-Stimulating Factor

Identifiers

PMID41760904
PMCPMC13043295

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.