Evidence map›Paper›PMID 41761321›Full record

ReviewJournal of ovarian research2026

Unraveling the mechanisms of PCOS: the interplay between gut microbiota and the immune system.

Jun Liu, Li Wang, Min Jiang, Heqiu Yan, Guohui Zhang, Ningjing Li, Yuhong Zhao, Xinrong Du, Qin Zeng, Dongsheng Xiong and 4 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of ovarian research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jun Liu *Reproductive Medicine Center, Key Laboratory of Reproductive Medicine, Sichuan Provincial Woman's and Children's Hospital, the Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu, Sichuan, 610045, China.
Li Wang *Reproductive Medicine Center, Key Laboratory of Reproductive Medicine, Sichuan Provincial Woman's and Children's Hospital, the Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu, Sichuan, 610045, China.
Min JiangReproductive Medicine Center, Key Laboratory of Reproductive Medicine, Sichuan Provincial Woman's and Children's Hospital, the Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu, Sichuan, 610045, China.
Heqiu YanReproductive Medicine Center, Key Laboratory of Reproductive Medicine, Sichuan Provincial Woman's and Children's Hospital, the Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu, Sichuan, 610045, China.
Guohui ZhangReproductive Medicine Center, Key Laboratory of Reproductive Medicine, Sichuan Provincial Woman's and Children's Hospital, the Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu, Sichuan, 610045, China.
Ningjing LiReproductive Medicine Center, Key Laboratory of Reproductive Medicine, Sichuan Provincial Woman's and Children's Hospital, the Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu, Sichuan, 610045, China.
Yuhong ZhaoReproductive Medicine Center, Key Laboratory of Reproductive Medicine, Sichuan Provincial Woman's and Children's Hospital, the Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu, Sichuan, 610045, China.
Xinrong DuReproductive Medicine Center, Key Laboratory of Reproductive Medicine, Sichuan Provincial Woman's and Children's Hospital, the Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu, Sichuan, 610045, China.
Qin ZengReproductive Medicine Center, Key Laboratory of Reproductive Medicine, Sichuan Provincial Woman's and Children's Hospital, the Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu, Sichuan, 610045, China.
Dongsheng XiongReproductive Medicine Center, Key Laboratory of Reproductive Medicine, Sichuan Provincial Woman's and Children's Hospital, the Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu, Sichuan, 610045, China.
Libing HeReproductive Medicine Center, Key Laboratory of Reproductive Medicine, Sichuan Provincial Woman's and Children's Hospital, the Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu, Sichuan, 610045, China.
Zhuoting ZhouReproductive Medicine Center, Key Laboratory of Reproductive Medicine, Sichuan Provincial Woman's and Children's Hospital, the Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu, Sichuan, 610045, China.
Mengjun LuoDepartment of Clinical Laboratory, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, No. 1617 Ri Yue Street, Chengdu, Sichuan, 611731, China. luomengjun2023@163.com.
Weixin LiuReproductive Medicine Center, Key Laboratory of Reproductive Medicine, Sichuan Provincial Woman's and Children's Hospital, the Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu, Sichuan, 610045, China. liuweixind@163.com.

Funding

Sichuan Provincial Postdoctoral Research Project Special Funding grant no. TB2025040Sichuan Provincial Science and Technology Department Central Guidance Local Science and Technology Development Project 2024ZYD0067The Key project of Sichuan Science and Technology Department 2023YFS0057Youth Innovation Project of Sichuan Medical Association Q2024012
6 · The paper itself

Abstract

Polycystic ovary syndrome(PCOS), a reproductive endocrine disorder that affects fertility in women of reproductive age, is characterized by high prevalence, diverse clinical manifestations, and unclear mechanisms. Elucidating its pathogenesis is of great significance for the treatment and prevention of PCOS. The gut microbiota, as a key modulator of human metabolism, plays a crucial role in PCOS through its interactions with the immune system. Gut microbiota and its metabolites not only serve as essential components of human metabolism but also act as critical regulators of the immune system. Therefore, this review focuses on the role of gut microbiota and the immune system in the pathogenesis of PCOS. It highlights the interactions between gut microbiota and its metabolites (such as lipopolysaccharides, branched-chain amino acids, and short-chain fatty acids) with the immune system, and their effects on key symptoms of PCOS, including inflammation, ovarian dysfunction, and insulin resistance. Furthermore, potential therapeutic strategies for alleviating PCOS are discussed, aiming to provide guidance for the treatment and prevention of PCOS.

Indexed as

Gastrointestinal MicrobiomeImmune SystemPolycystic Ovary SyndromeAnimalsFemaleHumansInsulin ResistanceGut microbiotaImmune systemPolycystic ovary syndrome

Identifiers

PMID41761321
PMCPMC13374169

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.