Evidence map›Paper›PMID 41761630›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Time-Resolved SAXS Reveals Distinct Millisecond Metal-Induced Conformational Dynamics of Monomeric α-Synuclein.

Rebecca Sternke-Hoffmann, Miriam Dos Santos Pinto, Xue Wang, Jinghui Luo

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rebecca Sternke-HoffmannPSI Center for Life Sciences, Villigen PSI, Switzerland.ORCID https://orcid.org/0000-0002-1662-8244
Miriam Dos Santos PintoPSI Center for Life Sciences, Villigen PSI, Switzerland.
Xue WangPSI Center for Life Sciences, Villigen PSI, Switzerland.
Jinghui LuoPSI Center for Life Sciences, Villigen PSI, Switzerland.ORCID https://orcid.org/0000-0002-7014-8153

Funding

Swiss National Scientific Foundation 10002967Swiss National Scientific Foundation 310030_197626
6 · The paper itself

Abstract

Transition metal ions have been implicated in modulation the conformational behavior and aggregation of WT α-synuclein (WT-αSyn), associated with Parkinson's disease pathology. Nevertheless, the initial structural rearrangements that drive aggregation are not fully understood. Here, we employed time-resolved small-angle X-ray scattering (TR-SAXS) in a microfluidic setup to investigate the structural dynamics of monomeric WT-αSyn upon interaction with Mn

Indexed as

alpha-SynucleinMetalsHumansProtein ConformationScattering, Small AngleX-Ray Diffractionalpha-SynucleinMetalsconformational dynamicsintrinsically disordered proteinsmetal ionsprotein‐metal interactiontime‐resolved SAXSα‐synuclein

Identifiers

PMID41761630
PMCPMC13137826

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.