Evidence map›Paper›PMID 41761847›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Left ventricular remodeling and diastolic dysfunction predict cognitive decline in older adults.

Arshama Dehghan, Fernando R Giugni, Katja Vu Bartholdy, Yimin Yang, Victoria Lamberson, Wendy Wang, Brian Claggett, Ihab Hajjar, Thomas Mosley, Priya Palta and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Arshama DehghanDepartment of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, USA.
Fernando R GiugniDepartment of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, USA.
Katja Vu BartholdyHerlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Yimin YangDepartment of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, USA.
Victoria LambersonDepartment of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, USA.
Wendy WangDepartment of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, USA.
Brian ClaggettBrigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Ihab HajjarDepartment of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, USA.
Thomas MosleyThe MIND Center, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Priya PaltaDepartment of Neurology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Lin Yee ChenCardiovascular Division and Lillehei Heart Institute, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
Amil M ShahDepartment of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, USA.

Funding

ARIC Neurocognitive Study (ARIC-NCS) Renewal 2023-2028U01HL096812 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JOSEF CORESH, THOMAS H MOSLEY · 2010 to 2026
$65.7M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - COORDINATING CENTER - TASK AREA B.2 AND B.375N92022D00001 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID · 2022 to 2025
$13.7M
ARIC Neurocognitive Study (ARIC-NCS) Renewal 2 of 5U01HL096917 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI MOSLEY, THOMAS H · 2010 to 2018
$11.9M
Mapping the Progression to HFpEF in the Elderly through Longitudinal Changes in Cardiac FunctionR01HL135008 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI Amil M Shah · 2017 to 2026
$11.5M
ARIC Neurocognitive Study (ARIC-NCS) Renewal UNC 4 of 5U01HL096899 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID J · 2010 to 2018
$7.5M
ARIC Neurocognitive Study (ARIC-NCS)U01HL096902 · NHLBI · UNIVERSITY OF MINNESOTA · PI LUTSEY, PAMELA L. · 2010 to 2018
$7.4M
ARIC Neurocognitive Study (ARIC-NCS) Renewal 4 of 5U01HL096814 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HUGHES, TIMOTHY M., WAGENKNECHT, LYNNE E · 2010 to 2018
$6.5M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A75N92022D00003 · NHLBI · UNIVERSITY OF MINNESOTA · PI LUTSEY, PAMELA L. · 2022 to 2025
$5.1M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A75N92022D00005 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI WAGENKNECHT, LYNNE E · 2022 to 2025
$5.0M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A75N92022D00004 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI WINDHAM, BEVERLY GWEN · 2022 to 2025
$4.8M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A75N92022D00002 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI CORESH, JOSEF · 2022 to 2025
$4.7M
Cognitive Impairment and Dementia, Vascular Brain Injury, and Atrial Myopathy: Implications for Prevention of Alzheimer's Disease-Related DementiasRF1NS135615 · NINDS · UNIVERSITY OF MINNESOTA · PI CHEN, LIN YEE, MOSLEY, THOMAS H · 2023 to 2023
$4.4M
National Heart, Lung, and Blood Institute (NHLBI) U01HL096812National Heart, Lung, and Blood Institute (NHLBI) U01HL096814National Heart, Lung, and Blood Institute (NHLBI) U01HL096899National Heart, Lung, and Blood Institute (NHLBI) U01HL096902National Heart, Lung, and Blood Institute (NHLBI) U01HL096917NHLBI NIH HHS 75N92022D00001NHLBI NIH HHS 75N92022D00002NHLBI NIH HHS 75N92022D00003NHLBI NIH HHS 75N92022D00004NHLBI NIH HHS 75N92022D00005NHLBI NIH HHS K24 HL152008NHLBI NIH HHS R01 HL135008NHLBI NIH HHS R01 HL143224NHLBI NIH HHS R01 HL148218NHLBI NIH HHS R01 HL150342NHLBI NIH HHS R01 HL172495NHLBI NIH HHS U01 HL096812NHLBI NIH HHS U01 HL096814NHLBI NIH HHS U01 HL096899NHLBI NIH HHS U01 HL096902NHLBI NIH HHS U01 HL096917NIH/NHLBI K24HL152008NIH/NHLBI R01HL135008NIH/NHLBI R01HL143224NIH/NHLBI R01HL148218NIH/NHLBI R01HL150342NIH/NHLBI R01HL172495NIH/NHLBI RF1NS135615NIH (NHLBI, National Institue of Neurological Disorders and Stroke (NINDS), National Institute on Aging, and National Institute on Deafness and Other Communication Disorders) U01HL096812NIH (NHLBI, National Institue of Neurological Disorders and Stroke (NINDS), National Institute on Aging, and National Institute on Deafness and Other Communication Disorders) U01HL096814NIH (NHLBI, National Institue of Neurological Disorders and Stroke (NINDS), National Institute on Aging, and National Institute on Deafness and Other Communication Disorders) U01HL096899NIH (NHLBI, National Institue of Neurological Disorders and Stroke (NINDS), National Institute on Aging, and National Institute on Deafness and Other Communication Disorders) U01HL096902NIH (NHLBI, National Institue of Neurological Disorders and Stroke (NINDS), National Institute on Aging, and National Institute on Deafness and Other Communication Disorders) U01HL096917NINDS NIH HHS RF1 NS135615
6 · The paper itself

Abstract

introductionAssociations of cardiac structure and function with longitudinal changes in cognitive function are not known.

methodsAmong 4957 participants (age 75 ± 5 years) in the Atherosclerosis Risk in Communities study free of stroke, heart failure, and dementia who underwent protocol echocardiography and neurocognitive testing at study Visit 5 and repeat neurocognitive testing at three follow-up visits over 10 years, factor scores were derived for executive function, memory, and language and averaged into a global score. We assessed associations using multivariable linear mixed models.

resultsGreater left ventricular mass index, higher left atrial (LA) volume index, and lower LA reservoir strain were associated with greater decline in global cognition (p < 0.01), driven by decline in executive function. Lower ejection fraction and e' velocity associated with greater decline in memory. DISCUSSION: Subclinical left ventricular remodeling and diastolic dysfunction are associated with greater decline in cognitive function over 10 years in late life. HIGHLIGHTS: LV remodeling and diastolic dysfunction are associated with accelerated cognitive decline. This association is driven by associations with accelerated decline in EF. Lower ejection fraction and e' velocity are associated with accelerated decline in memory.

Indexed as

Cognitive DysfunctionVentricular Dysfunction, LeftVentricular RemodelingAgedAged, 80 and overDiastoleEchocardiographyExecutive FunctionFemaleHumansLongitudinal StudiesMaleNeuropsychological TestsStroke VolumeAtherosclerosis Risk in Communities Neurocognitive Studycardiac remodelingcognitioncognitive declinediastolic functionechocardiographyexecutive functionlanguageleft atrial strainleft ventricular masslongitudinal cohortmemoryolder adults

Identifiers

PMID41761847
PMCPMC12949455

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.