Evidence map›Paper›PMID 41762004›Full record

ReviewJournal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG2026

Periorbital heliotrope erythema with edema as a potential clinical marker of paraneoplastic Dermatomyositis - a case series.

Antigona Aliu, Ulrich Peter Wehry, Frank Oellig, Thilo Gambichler, Sven-Niklas Burmann, Milan Vidakovic, Julian Kionke, Jörg H W Distler, Andrea-Hermina Györfi, Valentina Laura Müller and 1 more

Abstract readReview
In one paragraph

Review in Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Exuberant Infraorbital Edema Unmasking Paraneoplastic Dermatomyositis.International journal of rheumatic diseases · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Antigona AliuDepartment of Dermatology, Venerology and Allergology, Helios St. Elisabeth Hospital Oberhausen, University Witten/Herdecke.
Ulrich Peter WehryDepartment of Dermatology, Venerology and Allergology, Helios St. Elisabeth Hospital Oberhausen, University Witten/Herdecke.
Frank OelligInstitute of Pathology Mülheim, Mülheim an der Ruhr.
Thilo GambichlerDepartment of Dermatology, Dortmund Hospital gGmbH, University Witten/Herdecke, Dortmund.
Sven-Niklas BurmannDepartment of Dermatology, Venerology and Allergology, Helios St. Elisabeth Hospital Oberhausen, University Witten/Herdecke.
Milan VidakovicDepartment of Dermatology, Venerology and Allergology, Helios St. Johannes Hospital Duisburg.
Julian KionkeDepartment of Dermatology, Venerology and Allergology, Helios St. Johannes Hospital Duisburg.
Jörg H W DistlerDepartment of Rheumatology and Hiller Research Center, University Hospital Düsseldorf, Medical Faculty of Heinrich-Heine-University, Dusseldorf, Germany.
Andrea-Hermina GyörfiDepartment of Rheumatology and Hiller Research Center, University Hospital Düsseldorf, Medical Faculty of Heinrich-Heine-University, Dusseldorf, Germany.
Valentina Laura MüllerDepartment of Dermatology, Venerology and Allergology, Helios St. Johannes Hospital Duisburg.
Alexander KreuterDepartment of Dermatology, Venerology and Allergology, Helios St. Elisabeth Hospital Oberhausen, University Witten/Herdecke.ORCID https://orcid.org/0000-0003-2275-499X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adult-onset dermatomyositis (DM) is frequently associated with underlying malignancies, especially in individuals with anti-TIF1-γ or anti-NXP-2 autoantibodies. This case series describes 10 cases of DM with periorbital heliotropic erythema and eyelid edema (PHEEE), in which an underlying malignancy was confirmed by imaging in 9 patients. By incorporating additional serological markers and clinical characteristics described in the literature, a simple criteria list is provided to aid in the assessment of a paraneoplastic etiology in DM. The presence of PHEE appears to constitute a clinically relevant indicator of paraneoplastic DM and requires careful screening for malignancy.

Indexed as

DermatomyositisEdemaErythemaEyelid DiseasesParaneoplastic SyndromesAdultAgedAutoantibodiesBiomarkersFemaleHumansMaleMiddle AgedAutoantibodiesBiomarkersanti‐NXP‐2anti‐TIF1‐γdermatomyositisheliotrope erythemalid edemaparaneoplastic syndrome

Identifiers

PMID41762004
PMCPMC13352468

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.