ArticleThe Journal of biological chemistry2026
Glycosphingolipids in human abdominal leiomyosarcoma and liposarcoma.
Article in The Journal of biological chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Retroperitoneal sarcomas (liposarcomas and leiomyosarcomas) are rare and highly malignant mesenchymal tumors with poor prognosis, since they often reach a large size before detection, due to their anatomical location. Thus, development of new tumor biomarkers for early detection of these cancers is urgently needed. In search for potential sarcoma biomarkers, this study examined the glycosphingolipid profiles of one leiomyosarcoma and one liposarcoma by mass spectrometry, enzymatic hydrolysis, and by binding of carbohydrate-recognizing ligands. Detailed mass spectrometry analyses of oligosaccharides released from the glycosphingolipids showed that the liposarcoma had a number of glycosphingolipids previously found in many human tissues (the gangliosides GM3, GD3, GM2, GD1a, sialylneolactotetra- and hexaosylceramide, globo- and lactotriaosylceramide, globo- and lactotetraosylceramide, x
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