ArticleGut microbes2026
Intestinal epithelial TLR4 knock out induces sex-specific effects on gut barrier and microbiome in an activity-based anorexia model.
Colin Salaün, Marion Huré, Charlène Guérin, Christine Bôle-Feysot, Audrey Valentin, Fatima Léon, Sarah Lenoir, Jean-Luc do-Rego, Jean-Claude do-Rego, Ludovic Langlois and 3 more
Abstract read
In one paragraphArticle in Gut microbes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from itWhat it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
13 authors.
Colin SalaünINSERM, Normandie Université, ADEN UMR1073 'Nutrition, Inflammation and microbiota-gut-brain axis', Univ Rouen Normandie, Rouen, France.ORCID 0000-0002-7414-335X Marion HuréINSERM, Normandie Université, ADEN UMR1073 'Nutrition, Inflammation and microbiota-gut-brain axis', Univ Rouen Normandie, Rouen, France.ORCID 0009-0004-9251-7214 Charlène GuérinINSERM, Normandie Université, ADEN UMR1073 'Nutrition, Inflammation and microbiota-gut-brain axis', Univ Rouen Normandie, Rouen, France.ORCID 0000-0003-0585-8754 Christine Bôle-FeysotINSERM, Normandie Université, ADEN UMR1073 'Nutrition, Inflammation and microbiota-gut-brain axis', Univ Rouen Normandie, Rouen, France.
Audrey ValentinINSERM, Normandie Université, ADEN UMR1073 'Nutrition, Inflammation and microbiota-gut-brain axis', Univ Rouen Normandie, Rouen, France.
Fatima LéonInstitute for research and Innovation in Biomedicine (IRIB), Univ Rouen Normandie, Rouen, France.
Sarah LenoirINSERM, Normandie Université, ADEN UMR1073 'Nutrition, Inflammation and microbiota-gut-brain axis', Univ Rouen Normandie, Rouen, France.
Jean-Luc do-RegoInstitute for research and Innovation in Biomedicine (IRIB), Univ Rouen Normandie, Rouen, France.
Jean-Claude do-RegoInstitute for research and Innovation in Biomedicine (IRIB), Univ Rouen Normandie, Rouen, France.
Ludovic LangloisINSERM, Normandie Université, ADEN UMR1073 'Nutrition, Inflammation and microbiota-gut-brain axis', Univ Rouen Normandie, Rouen, France.
David RibetINSERM, Normandie Université, ADEN UMR1073 'Nutrition, Inflammation and microbiota-gut-brain axis', Univ Rouen Normandie, Rouen, France.ORCID 0000-0003-1175-6471 Najate AchamrahINSERM, Normandie Université, ADEN UMR1073 'Nutrition, Inflammation and microbiota-gut-brain axis', Univ Rouen Normandie, Rouen, France.ORCID 0000-0003-4941-0564 Moïse CoëffierINSERM, Normandie Université, ADEN UMR1073 'Nutrition, Inflammation and microbiota-gut-brain axis', Univ Rouen Normandie, Rouen, France.ORCID 0000-0002-7469-2682 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
The role of the microbiota‒gut‒brain axis in the pathophysiology of anorexia nervosa has emerged in recent decades. Increased expression of Toll-like receptor 4 (TLR4) has been reported in the intestinal epithelial cells (IEC) of activity-based anorexia (ABA) mice. The inducible TLR4 knockout in IEC (TLR4
Indexed as
AnorexiaGastrointestinal MicrobiomeIntestinal MucosaToll-Like Receptor 4AnimalsBacteriaColonDisease Models, AnimalFemaleIntestinal Barrier FunctionMaleMiceMice, Inbred C57BLMice, KnockoutSex FactorsTlr4 protein, mouseToll-Like Receptor 4activity-based anorexia miceAnorexia nervosagut barriergut inflammationgut microbiotaTLR4
Identifiers
PMID41764036
PMCPMC12959196
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