Evidence map›Paper›PMID 41764143›Full record

ArticlePediatric nephrology (Berlin, Germany)2026

Nutrition delivery in infants with kidney failure on extracorporeal kidney replacement therapy.

Samantha L Krieger, Melissa S Zhou, Laura Popovich, Cynthia Wong, Alexis S Davis, Scott M Sutherland, Shina Menon

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Article in Pediatric nephrology (Berlin, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Samantha L KriegerDivision of Nephrology, Department of Pediatrics, Stanford University, Palo Alto, CA, USA.
Melissa S ZhouDivision of Nephrology, Department of Pediatrics, Stanford University, Palo Alto, CA, USA.
Laura PopovichDivision of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University, Palo Alto, CA, USA.
Cynthia WongDivision of Nephrology, Department of Pediatrics, Stanford University, Palo Alto, CA, USA.
Alexis S DavisDivision of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University, Palo Alto, CA, USA.
Scott M SutherlandDivision of Nephrology, Department of Pediatrics, Stanford University, Palo Alto, CA, USA.
Shina MenonDivision of Nephrology, Department of Pediatrics, Stanford University, Palo Alto, CA, USA. shinam@stanford.edu.ORCID http://orcid.org/0000-0001-8473-0307

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInfants with kidney failure who initiate kidney replacement therapy (KRT) within 3 months of life require optimal fluid and nutritional management to support growth. Continuous or prolonged intermittent KRT (CKRT or PIKRT) is often used as a bridge to peritoneal dialysis facilitating earlier nutrition provision but is associated with protein losses. Current guidelines recommend ≥ 3-3.5 g/kg/day of protein during KRT. We aimed to assess nutritional prescriptions and growth in these infants.

methodsWe conducted a retrospective review of infants with kidney failure managed with extracorporeal KRT at Lucile Packard Children's Hospital between January 2021 and December 2024. Demographics, dialysis dose, nutrition prescriptions, anthropometry, and laboratory values were collected weekly from birth through 8 weeks and at discharge.

resultsSeventeen infants were included; 12 (71%) were female. KRT was initiated at a median age of 3 days and a median weight of 2110 g. Initial modality was PIKRT in 15 (88%) and CKRT in 2 (12%). The median prescribed protein was 2.7 g/kg/day in Week 1, increasing to 4 g/kg/day by Week 6. Caloric prescriptions rose from 95 kcal/kg/day in Week 1 to 136 kcal/kg/day by Week 8. Median z-scores for weight, length, and head circumference decreased from birth to Week 8 (weight - 1.07 to - 1.34; length - 1.02 to - 1.95; head circumference - 0.41 to - 1.36), with discharge values of - 1.08, - 1.73, and - 1.40.

conclusionsDespite early KRT and nutritional optimization, infants showed limited catch-up growth. Early provision of ≥ 4 g/kg/day protein and ≥ 130 kcal/kg/day may prevent cumulative deficits.

Indexed as

Renal InsufficiencyRenal Replacement TherapyDietary ProteinsFemaleHumansInfantInfant, NewbornMaleRetrospective StudiesDietary ProteinsGrowthKidney failureNeonatal renal replacement therapyNutrition

Identifiers

PMID41764143

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.