Higher-molecular-weight a-synuclein oligomers are increased in the brain cytosol of patients with dementia with Lewy bodies.

Emil Gregersen, Mia R Antorini, Lasse Reimer, Ludovica Zaccagnini, Dennis Selkoe, Tim Bartels, Poul Henning Jensen

Abstract read

In one paragraph

Article in NPJ Parkinson's disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Seeing Invisible Oligomers: Rethinking α-Synuclein Pathology Through Proximity Ligation Assay.Movement disorders : official journal of the Movement Disorder Society · 2026
Review

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Emil Gregersen *Danish Research Institute of Translational Neuroscience - DANDRITE, Aarhus University, Aarhus, Denmark.

Mia R Antorini *Danish Research Institute of Translational Neuroscience - DANDRITE, Aarhus University, Aarhus, Denmark.

Lasse ReimerDanish Research Institute of Translational Neuroscience - DANDRITE, Aarhus University, Aarhus, Denmark.

Ludovica ZaccagniniDepartment of Neurology, UK Dementia Research Institute, University College London, London, UK.

Dennis SelkoeDepartment of Neurology, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Tim BartelsDepartment of Neurology, UK Dementia Research Institute, University College London, London, UK.

Poul Henning JensenDanish Research Institute of Translational Neuroscience - DANDRITE, Aarhus University, Aarhus, Denmark. phj@biomed.au.dk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The demonstration of MJFR14-6-4-2 proximity ligation assay positive aggregates in brains affected by Parkinson's disease and LRRK2 mutations, motivated the analysis of α-synuclein oligomers in brain cytosol from dementia with Lewy bodies (DLB) and control cases by combining size-exclusion chromatography, aggregate-specific MJFR14-6-4-2 ELISA and SDS-denaturing immunoblotting. We demonstrate a DLB-specific accumulation of large SDS-soluble oligomers, and the presence of medium-sized oligomers consisting of SDS-resistant α-synuclein dimers and trimers in both DLB and controls.

Identifiers

PMID41764273

DOI10.1038/s41531-026-01301-2

PMCPMC13065805

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.