METTL3-mediated GLUD1 m6A Modification Promotes Hydrogen Peroxide-induced Mitochondrial Dysfunction in Human Nucleus Pulposus Cells Via the Glutamate/α-KG Metabolic Axis.

Ming Bai, Yimin Wu, Yang Zhang, Haibin Zhang, Peng Wang, Shuwen Li

Abstract read

In one paragraph

Article in Journal of musculoskeletal & neuronal interactions, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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5 · Who and what money

Authors and funding

6 authors.

Ming BaiSection C, Spine Surgery Center, the Second Affiliated Hospital of Inner Mongolia Medical University, China.

Yimin WuSection C, Spine Surgery Center, the Second Affiliated Hospital of Inner Mongolia Medical University, China.

Yang ZhangSection C, Spine Surgery Center, the Second Affiliated Hospital of Inner Mongolia Medical University, China.

Haibin ZhangSection C, Spine Surgery Center, the Second Affiliated Hospital of Inner Mongolia Medical University, China.

Peng WangSection C, Spine Surgery Center, the Second Affiliated Hospital of Inner Mongolia Medical University, China.

Shuwen LiSection C, Spine Surgery Center, the Second Affiliated Hospital of Inner Mongolia Medical University, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesHuman nucleus pulposus cells (HNPCs), the primary cellular constituents of the intervertebral disc, are central to the pathogenesis of intervertebral disc degeneration (IVDD). Oxidative stress-induced mitochondrial dysfunction leads to intracellular metabolic imbalance and has been implicated in IVDD. This study investigated the role and molecular mechanism of glutamate dehydrogenase 1 (GLUD1) in hydrogen peroxide (H

methodsHNPCs were exposed to H

resultsH

conclusionGLUD1 protects HNPCs from H

Indexed as

Glutamate DehydrogenaseGlutamic AcidHydrogen PeroxideKetoglutaric AcidsMethyltransferasesMitochondriaNucleus PulposusCells, CulturedHumansMembrane Potential, MitochondrialOxidative StressGLUD1 protein, humanGlutamate DehydrogenaseGlutamic AcidHydrogen PeroxideKetoglutaric AcidsMethyltransferasesGLUD1Glutamate/α-KG axisHuman Nucleus Pulposus CellsIntervertebral Disc DegenerationMitochondrial Dysfunction

Identifiers

PMID41764762

PMCPMC12952510

What Socratic holds

Textmetadata

LicenceCC BY-NC-SA

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.