Roles of synaptic cell adhesion molecules in the neuromodulatory systems.

Jennifer Li, Yuka Imamura Kawasawa, Motokazu Uchigashima, Kensuke Futai

Abstract readReview

In one paragraph

Review in Molecules and cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

A decade of discovery: Deciphering the synaptic adhesion code.Molecules and cells · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jennifer LiDepartment of Neurobiology, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, 366 Plantation Street, Worcester, MA 01605, USA.

Yuka Imamura KawasawaDepartment of Neuroscience and Experimental Therapeutics, Penn State College of Medicine, 500 University Dr., Hershey, PA 17033, USA.

Motokazu UchigashimaDepartment of Cellular Neuropathology, Brain Research Institute, Niigata University, Niigata 951-8585, Japan; International Research Center for Neurointelligence (WPI-IRCN), The University of Tokyo, Tokyo 113-0033, Japan. Electronic address: uchigashima@bri.niigata-u.ac.jp.

Kensuke FutaiDepartment of Neurobiology, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, 366 Plantation Street, Worcester, MA 01605, USA. Electronic address: Kensuke.Futai@umassmed.edu.

Funding

Molecular Mechanisms Underlying the sex-Depended Maturation of Modulatory Systems.R01MH130582 · NIMH · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KENSUKE FUTAI · 2022 to 2026

$2.9M

NIMH NIH HHS R01 MH130582

6 · The paper itself

Abstract

Synaptic cell-adhesion molecules (CAMs), also known as trans-synaptic adhesion molecules, are essential for synapse development and maintenance by physically linking presynaptic terminals to postsynaptic structures. Extensive research has established that synaptic CAMs are critical for the formation and function of various synapse types, particularly glutamatergic and GABAergic synapses. However, their roles within modulatory systems, such as dopaminergic (DA) and serotonergic (5-HT) circuits, which utilize both synaptic and non-synaptic (volume) transmission, remain poorly understood. In this mini review, we analyzed published single-cell transcriptomic datasets of DA and 5-HT neurons to characterize presynaptic CAM expression in these systems. We further summarized current knowledge regarding the contribution of presynaptic CAMs to DA and 5-HT function and discuss how postsynaptic CAM-mediated mechanisms shape dopaminergic synaptic architecture.

Indexed as

Cell Adhesion MoleculesSynapsesAnimalsHumansSynaptic TransmissionCell Adhesion MoleculesAutism spectrum disorderDopamineNeurodevelopmental disordersSerotoninTrans-synaptic adhesion molecules

Identifiers

PMID41765140

DOI10.1016/j.mocell.2026.100340

PMCPMC13014944

What Socratic holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.