Evidence map›Paper›PMID 41765633›Full record

ArticleAnalytica chimica acta2026

High-throughput simultaneous quantification of glycopeptides and phosphopeptides enabled by 12-plex DiLeu isobaric tags and dual-functional Titanium(IV)-IMAC material.

Feixuan Wu, Danqing Wang, Dylan Nicholas Tabang, Peng-Kai Liu, Zicong Wang, Yuan Liu, Angelique Steenhagen, Luigi Puglielli, Lingjun Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytica chimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. High-Throughput Proteomic and Glycoproteomic Analyses in Benign Prostatic Hyperplasia.Journal of the American Society for Mass Spectrometry · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Feixuan WuSchool of Pharmacy, University of Wisconsin-Madison, Madison, WI, 53705, USA.
Danqing WangDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Dylan Nicholas TabangDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA; Department of Pathology, Boston Children's Hospital & Harvard Medical School, Boston, MA, 02115, USA.
Peng-Kai LiuBiophysics Graduate Program, University of Wisconsin-Madison, WI, 53706, USA.
Zicong WangSchool of Pharmacy, University of Wisconsin-Madison, Madison, WI, 53705, USA.
Yuan LiuSchool of Pharmacy, University of Wisconsin-Madison, Madison, WI, 53705, USA.
Angelique SteenhagenDepartment of Medicine, University of Wisconsin-Madison, Madison, WI, 53705, USA; Waisman Center, University of Wisconsin-Madison, Madison, WI, 53705, USA.
Luigi PuglielliDepartment of Medicine, University of Wisconsin-Madison, Madison, WI, 53705, USA; Waisman Center, University of Wisconsin-Madison, Madison, WI, 53705, USA; Geriatric Research Education Clinical Center, Veterans Affairs Medical Center, Madison, WI, 53705, USA.
Lingjun LiSchool of Pharmacy, University of Wisconsin-Madison, Madison, WI, 53705, USA; Department of Chemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA; Biophysics Graduate Program, University of Wisconsin-Madison, WI, 53706, USA; Lachman Institute for Pharmaceutical Development, School of Pharmacy, University of Wisconsin-Madison, Madison, WI, 53705, USA; Wisconsin Center for NanoBioSystems, School of Pharmacy, University of Wisconsin-Madison, Madison, WI, 53705, USA. Electronic address: lingjun.li@wisc.edu.

Funding

TR&D 2 Metabolic Labels for Ultraplexed Protein Quantification p. 453P41GM108538 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI COON, JOSHUA J · 2016 to 2025
$13.1M
Mass Spectrometric Studies of Neuropeptides in FeedingR01DK071801 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI LINGJUN LI · 2006 to 2026
$6.7M
Spastic paraplegia, neurodegeneration and autism: possible role for AT- 1/SLC33A1?R01NS094154 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI Luigi Puglielli · 2015 to 2026
$4.3M
Creating a region- specific biomolecular atlas of the brain of Alzheimer’s diseaseR01AG078794 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI LINGJUN LI, Luigi Puglielli · 2022 to 2026
$3.7M
DiLeu-enabled multiplexed quantitation for biomarker discovery and validation in Alzheimer’s diseaseR01AG052324 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI LINGJUN LI · 2023 to 2026
$2.3M
Acquisition of a High-Field Dual Source FTICR-MS for Pharmaceutical ResearchS10RR029531 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI LI, LINGJUN · 2011 to 2011
$2.1M
Acquisition of a Dual-Source, High-Performance, Ion Mobility, Quadrupole Time-of-Flight Mass Spectrometry System for Biomedical Research at UW-MadisonS10OD028473 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI LI, LINGJUN · 2021 to 2021
$1.3M
ATase1 and ATase2, proteostasis, and neurological diseasesR01GM148487 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Luigi Puglielli · 2023 to 2026
$1.2M
Acquisition of a High Resolution High Speed MALDI Mass Spectrometer for Biomedical Research at UW-MadisonS10OD025084 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI LI, LINGJUN · 2018 to 2018
$598k
NCRR NIH HHS S10 RR029531NIA NIH HHS R01 AG052324NIA NIH HHS R01 AG078794NIDDK NIH HHS R01 DK071801NIGMS NIH HHS P41 GM108538NIGMS NIH HHS R01 GM148487NIH HHS S10 OD025084NIH HHS S10 OD028473NINDS NIH HHS R01 NS094154
6 · The paper itself

Abstract

backgroundProtein glycosylation and phosphorylation are critical post-translational modifications (PTMs) that regulate diverse physiological and pathological processes, yet their comprehensive characterization remains challenging due to low abundance and poor ionization efficiency. Recent advances using epoxy-ATP-Ti

resultsWe developed a high-throughput workflow integrating epoxy-Ti SIGNIFICANCE AND NOVELTY: This integrated DiLeu isobaric labeling-epoxy-Ti

Indexed as

GlycopeptidesHigh-Throughput Screening AssaysLeucinePhosphopeptidesTitaniumAnimalsGlycosylationMiceMice, TransgenicPhosphorylationProtein Processing, Post-TranslationalGlycopeptidesLeucinePhosphopeptidesTitaniumEnrichmentGlycoproteomicsHigh-throughput isobaric tagging for quantitationImmobilized metal affinity chromatographyPhosphoproteomicsPost-translational modifications

Identifiers

PMID41765633
PMCPMC13296347

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.