Elucidating the mechanism of cefpodoxime-BSA interaction via a combination of multi-spectroscopic methods and molecular docking simulations.

Reem N El Gammal, Heba Elmansi, Ali A El-Emam, Mohammed E A Hammouda, Fathalla Belal

Abstract read

In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Reem N El GammalDepartment of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, 35516, Mansoura, Egypt.

Heba ElmansiPharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt. dr_heba85@hotmail.com.

Ali A El-EmamDepartment of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, 35516, Mansoura, Egypt.

Mohammed E A HammoudaDepartment of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, 35516, Mansoura, Egypt.

Fathalla BelalPharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This research provides a comprehensive elucidation of the molecular interaction between cefpodoxime (CFP) and bovine serum albumin (BSA) through an integrated approach combining computational docking and a suite of spectroscopic methods. Initial evidence from UV-Vis absorption spectroscopy confirmed a ground-state complex formation between the drug and the protein. Subsequent fluorescence quenching studies established a static quenching mechanism, with a binding constant (Kb) of 3.99 × 10

Indexed as

Anti-Bacterial AgentsCeftizoximeMolecular Docking SimulationSerum Albumin, BovineAnimalsBinding SitesCattleCefpodoximeProtein BindingSpectrometry, FluorescenceThermodynamicsAnti-Bacterial AgentsCefpodoximeCeftizoximeSerum Albumin, BovineBovine serum albuminCefpodoximeMulti-spectroscopic

Identifiers

PMID41765909

DOI10.1038/s41598-026-39137-8

PMCPMC12953881

What Socratic holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.