Evidence map›Paper›PMID 41766030›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2026

Angiotensin-converting enzyme inhibitors and angiotensin-receptor blockers usage is associated with a reduced risk of seizures and epilepsy after ischemic stroke.

Jiaxin Liu, Qian Liu, Xin Jiang, Yaowen Hu, Jinghan Xu, Yanbo Li, Mengmeng Ma, Jinghuan Fang, Dong Zhou, Li He

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Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Jiaxin Liu *Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.
Qian Liu *Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.
Xin JiangDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, China.
Yaowen HuDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, China.
Jinghan XuDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, China.
Yanbo LiDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, China.
Mengmeng MaDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, China.
Jinghuan FangDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, China.
Dong ZhouDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, China. zhoudong66@yahoo.de.
Li HeDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, China. heli2003new@126.com.ORCID http://orcid.org/0000-0002-2034-1027

Funding

China's Postdoctoral Science Foundation 2022M722265Sichuan Science and Technology Program 2022YFS0139Sichuan Science and Technology Program 2023NSFSC1562
6 · The paper itself

Abstract

backgroundIschemic stroke is the leading cause of epilepsy in the elderly. Various antihypertensive drugs have shown potential anti-epileptic effects and are widely used in cerebrovascular disease for the comorbidity of hypertension. However, it remains unknown whether they can reduce the occurrence of seizures and epilepsy after ischemic stroke.

objectiveTo examine the effect of antihypertensive drugs on reducing the risk of post-stroke early-onset seizures (ES) and post-stroke epilepsy (PSE).

designA retrospective cohort study.

methodsIn this retrospective cohort study, we enrolled patients who experienced a first-ever acute ischemic stroke and had no history of epilepsy prior to the stroke. With a mean follow-up period of 3.5 years, we identified occurrences of ES and PSE. Logistic regression analyses were employed to assess the potential efficacy of antihypertensive drugs in reducing the incidence of ES and PSE.

resultsOut of 888 enrolled patients, 19 (2.1%) developed ES and 27 (3.0%) developed PSE. The use of antihypertensive drugs was associated with a reduced risk of ES (OR 0.37, 95% CI 0.14-0.99, p = 0.047). Specifically, the use of renin-angiotensin system inhibitors, such as angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs), was associated with a 68% of decreased risk of PSE (OR 0.29, 95% CI 0.11-0.94), the significance remained after adjustment.

conclusionsThe use of antihypertensive drugs potentially decreases the risk of ES/PSE. Specifically, among all antihypertensive drugs, ACEI/ARBs could lower the likelihood of developing PSE.

Indexed as

Angiotensin-Converting Enzyme InhibitorsAngiotensin Receptor AntagonistsEpilepsyIschemic StrokeSeizuresStrokeAgedAged, 80 and overAntihypertensive AgentsBrain IschemiaFemaleFollow-Up StudiesHumansMaleMiddle AgedRetrospective StudiesAngiotensin-Converting Enzyme InhibitorsAngiotensin Receptor AntagonistsAntihypertensive AgentsAngiotensin-converting enzyme inhibitorsAntihypertensive drugsIschemic strokePost-stroke epilepsy

Identifiers

PMID41766030

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.