ArticleZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics2026
[Influencing factors and development of a predictive model for the progression of glomerular injury in children with Henoch-Schönlein purpura nephritis].
Article in Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesTo investigate the influencing factors for the progression of glomerular injury in children with Henoch-Schönlein purpura nephritis (HSPN) and to develop a predictive model.
methodsA total of 259 children with HSPN admitted to the First Affiliated Hospital of Henan University of Traditional Chinese Medicine from January 2022 to December 2024 were retrospectively enrolled. Based on renal biopsy pathology reports, the children were classified into a low-grade group (grade Ⅰ-Ⅱ glomerular injury;
resultsCompared with the low-grade group, the high-grade group showed significantly higher urinary red blood cell count, urinary cast count, urinary small round epithelial cell count, urine protein-to-creatinine ratio, urinary IgG-to-creatinine ratio, urinary N-acetyl-β-D-glucosaminidase, fibrinogen, white blood cell count, and neutrophil-to-lymphocyte ratio, while albumin, albumin-to-globulin ratio, and prothrombin time were significantly decreased (all
conclusionsChildren with higher-grade glomerular injury from HSPN exhibit more severe clinical and pathological manifestations. The prediction model incorporating urinary small round epithelial cell count, urine protein-to-creatinine ratio, fibrinogen level, albumin level, neutrophil-to-lymphocyte ratio, and dyslipidemia demonstrates good predictive performance for identifying progression to high-grade (Ⅲ-Ⅵ) glomerular injury and has potential for clinical application.
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