SynthesisObesity reviews : an official journal of the International Association for the Study of Obesity2026
A Systematic Review and Meta-Analysis of Semaglutide Effects on Adipose Tissue and Emerging Effects on Brain and Cognition.
Synthesis in Obesity reviews : an official journal of the International Association for the Study of Obesity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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15 authors.
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Abstract
backgroundIn 2023 and 2024, research into semaglutide (SEMA), an antiobesity and antidiabetic medication, indicated potential benefits beyond its approved uses, particularly in preventing Alzheimer's disease (AD). This highlights the link between obesity and AD development.
objectivesThis systematic review and meta-analysis evaluates clinical studies assessing SEMA's effects on subcutaneous and visceral adipose tissue (SAT/VAT) measures, brain function, cognitive performance through cognitive tasks, and the incidence of cognitive disorders.
methodsWe searched databases for studies evaluating these outcomes pre- and post-SEMA treatment, with the last update on November 9, 2024. We included studies regardless of treatment duration, estimating pre-post standardized mean differences (SMD) for one-group and two-group designs using a random-effects model.
resultsWe included 23 studies: 18 on SAT/VAT outcomes and five on brain function and cognitive impairment. Meta-analyses revealed significant VAT reductions but no significant impact on SAT. SEMA demonstrated neuroprotective effects, lowering the risk of AD compared to various treatments.
conclusionOur systematic appraisal highlighted high heterogeneity across available original investigations. Within this context, meta-analytic findings suggest that SEMA may be able to promote VAT loss and support cognitive preservation. Sequencing these effects, VAT loss and cognitive preservation, is an important question open for further exploration.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.