SynthesisFrontiers in immunology2026
Beneficial effects of a high-anthocyanin diet versus a Westernized diet on colorectal cancer risk: a systematic review.
Synthesis in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Beneficial effects of a high-anthocyanin diet versus a Westernized diet on colorectal cancer risk: a systematic review.Frontiers in immunology · 2026Pooled it
- Berry-derived Bioactive Compounds as Chemopreventive Agents in Colorectal Cancer: Molecular Mechanisms and Gut Microbiota Interactions.Journal of cancer prevention · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Colorectal cancer (CRC) is one of the leading causes of morbidity and mortality worldwide. Its incidence has been strongly associated with dietary patterns of the Western diet (WD), which are characterized by high intakes of saturated fats, ultra-processed foods, red and processed meats, refined grains, and added sugars. In contrast, numerous studies have highlighted the potential health benefits of anthocyanins-bioactive compounds with anti-inflammatory, antioxidant, and antitumoral properties. This systematic review aimed to evaluate the effects of anthocyanin-rich diets on CRC prevention and compare them with the effects of WD. Methods: A systematic search was conducted in PubMed, Scopus, and SciELO databases following PRISMA 2020 guidelines. Search terms included: "anthocyanin" OR "anthocyanins" AND "prevention" AND "colorectal cancer" AND "Western diet" AND "effect." Results: Sixteen studies met the inclusion criteria. Anthocyanin-rich interventions demonstrated consistent preventive effects, including the modulation of oxidative stress, suppression of oncogenic signaling pathways, induction of apoptosis in CRC cells, and restoration of gut barrier integrity and microbial diversity. Notably, these interventions exerted significant anti-inflammatory effects by downregulating pro-inflammatory cytokines, inhibiting NF-κB, and attenuating colitis-associated tumorigenesis. In contrast, Western dietary patterns were consistently associated with enhanced colonic inflammation, alterations in gut microbial composition, impairment of mucosal immune regulation, and increased colorectal tumor burden. Discussion: This systematic review provides evidence supporting the protective role of anthocyanin-rich diets in CRC prevention. However, further research is needed to examine drug-nutrient interactions in the context of comorbidities, evaluate various sources of anthocyanins, and better understand the factors influencing their bioavailability and absorption. Systematic Review Registration: https://osf.io/b56yz/overview, identifier osf-registrations-b56yz-v.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.