ArticleFrontiers in immunology2026
Born with two faces: sequential DLBCL, NOS and TFHL-AI with
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Diffuse large B-cell lymphoma, not otherwise specified (DLBCL, NOS) and nodal T follicular helper cell lymphoma, angioimmunoblastic type (TFHL-AI) share significant histopathological and pathogenetic similarities. However, the mechanisms underlying these overlaps remain insufficiently explored in the literature. We report the case of a 74-year-old man who initially presented with progressive sore throat and was diagnosed with DLBCL, NOS based on a tonsillar biopsy. He achieved complete remission following six cycles of R-CHOP chemotherapy (rituximab, cyclophosphamide, vindesine, liposomal doxorubicin, and dexamethasone). However, the patient was lost to follow-up. About two years later, he re-presented with generalized pruritus and lymphadenopathy. A cervical lymph node biopsy confirmed TFHL-AI. He received four cycles of the histone deacetylase inhibitor (HDACi) chidamide combined with COEP chemotherapy (cyclophosphamide, vindesine, etoposide, and prednisone), resulting in a partial remission. However, the disease subsequently progressed, and the patient passed away six months later, with a total overall survival of 35months. Next-generation sequencing (NGS) of biopsy specimens from both lymphoma types revealed shared
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