ArticleJournal of the Endocrine Society2026
Prenatal and postnatal atrazine-induced endocrine and ovarian chemical biotransformation protein disruption in offspring.
Article in Journal of the Endocrine Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Atrazine (ATZ) is an endocrine-disrupting chemical, and ATZ exposure during perinatal development is linked to reproductive dysfunction and behavioral abnormalities in adulthood. Gestational ATZ exposure can adversely affect birth weight, fetal growth, and onset of puberty. To investigate ovarian effects of ATZ exposure on female offspring, timed pregnant nulliparous gilts were provided ad libitum access to water that contained vehicle control (CT; 0.002% (v/v) ethanol; n = 3) or an environmentally relevant ATZ dose (20 µg/L; n = 4); thus piglets were exposed from gestation day 28 through farrowing and lactation (∼99 days). Umbilical cord blood serum was assayed for hormone concentrations, ovarian follicles were classified and counted, and abundance of proteins involved in folliculogenesis, steroidogenesis, chemical biotransformation, DNA damage, and cell viability in piglet ovaries were quantified by Western blotting. Exposure to ATZ decreased (
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