SynthesisFrontiers in neurology
Prevalence and incidence of orthostatic hypotension in patients with Parkinson's disease: an updated systematic review and meta-analysis.
Synthesis in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aim: Systematically quantifying the prevalence and incidence of orthostatic hypotension in Parkinson's disease patients. Background: Orthostatic hypotension is a common non-motor symptom in Parkinson's disease patients. Although systematic reviews have been published previously, existing data are outdated, and there is a lack of research examining differences in the prevalence and incidence of this symptom across various etiologies. An update of current studies is urgently needed. Design: Systematic review and meta-analysis. Methods: A systematic search was conducted across the following databases: Medline, PubMed, Web of Science, Embase, Cochrane Library, CINAHL, and ProQuest, retrieving English-language publications since each database's inception. Included studies comprised cross-sectional, retrospective cohort, and prospective cohort investigations reporting the prevalence or incidence of orthostatic hypotension in patients with Parkinson's disease. Results: This meta-analysis included 55 studies involving 10,463 patients with Parkinson's disease. The combined prevalence of orthostatic hypotension (OH) was 33% (95% Conclusion: Orthostatic hypotension is prevalent in Parkinson's disease with a combined prevalence of 33%, exhibiting considerable heterogeneity. This heterogeneity stems from variations in clinical practice and research methodologies. Our meta-analysis revealed that, at the pooled level, the prevalence of orthostatic hypotension showed no significant association with disease duration, MDS-UPDRS-III score and mean levodopa equivalent daily dose. However, this likely reflects inconsistencies in case definitions, timing of measurements, and measurement settings. Future studies must employ standardized autonomic assessment methods to accurately define neurogenic orthostatic hypotension and identify reliable clinical correlates. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD42025632838, identifier PROSPERO (CRD42025632838).
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.