Evidence map›Paper›PMID 41767173›Full record

ArticleJournal of asthma and allergy2026

The Hidden Pathway: Membrane Vitamin D Receptor Deficiency and T-Cell Senescence in Pediatric Atopic Dermatitis - A Retrospective and Cross-Sectional Investigation.

Xingyuan Zhu, Xiaofei Gao, Lili Wang, Jianping Tang, Lingli Luo, Qiang Yu, Bibo Qiu, Chuqiang Shu, Xieling He

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Article in Journal of asthma and allergy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Xingyuan ZhuDepartment of Laboratory Medicine, The Affiliated Children's Hospital of Xiangya School of Medicine, Hunan Children's Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Xiaofei GaoDepartment of Dermatology, The Affiliated Children's Hospital of Xiangya School of Medicine, Hunan Children's Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Lili WangDepartment of Medical Genetics, Clinical Medical Research Center for Hereditary Birth Defects and Rare Diseases in Hunan Province, The Affiliated Children's Hospital of Xiangya School of Medicine (Hunan Children's Hospital), Central South University, Changsha, Hunan, People's Republic of China.ORCID 0009-0007-3740-3929
Jianping TangDepartment of Dermatology, The Affiliated Children's Hospital of Xiangya School of Medicine, Hunan Children's Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Lingli LuoDepartment of Laboratory Medicine, The Affiliated Children's Hospital of Xiangya School of Medicine, Hunan Children's Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Qiang YuDepartment of Laboratory Medicine, The Affiliated Children's Hospital of Xiangya School of Medicine, Hunan Children's Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Bibo QiuDepartment of Laboratory Medicine, The Affiliated Children's Hospital of Xiangya School of Medicine, Hunan Children's Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Chuqiang ShuNational Health Commission Key Laboratory for Birth Defect Research and Prevention, Hunan Provincial Maternal and Child Health Care Hospital, Changsha, Hunan, People's Republic of China.
Xieling HeNational Health Commission Key Laboratory for Birth Defect Research and Prevention, Hunan Provincial Maternal and Child Health Care Hospital, Changsha, Hunan, People's Republic of China.ORCID 0000-0002-1904-7023

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Pediatric Atopic dermatitis (AD) is a common, relapsing inflammatory skin disease in children. While linked to vitamin D deficiency, the roles of T-cell senescence and vitamin D receptor (VDR) signaling remain unclear. Objective: To explore vitamin D status, VDR expression (soluble/sVDR, membrane/mVDR, nuclear/nVDR), and T-cell senescence in pediatric AD. Methods: Serum 25-hydroxyvitamin D (25(OH)D) levels were analyzed in 408 pediatric AD patients and matched controls. In a subset (89 patients, 35 controls), plasma sVDR was measured by ELISA. T-cell immunophenotyping, senescence markers (CD27 Results: Children with AD had significantly lower serum 25(OH)D ( Conclusion: Pediatric AD is characterized by accelerated T-cell senescence and a widespread mVDR pathway deficiency. This receptor defect, coupled with vitamin D deficiency, may drive immune dysregulation and premature T-cell aging, highlighting potential therapeutic targets in both ligand and receptor pathways.

Indexed as

25-hydroxyvitamin Dpediatric atopic dermatitissenescenceT cellvitamin D receptor

Identifiers

PMID41767173
PMCPMC12949577

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.