Evidence map›Paper›PMID 41767264›Full record

ArticleiScience2026

Estrogen upregulates NR4A1 to counter TGF beta induced pulmonary fibrosis therapeutic insights for IPF.

Bao Liu, Haoran Chi, Tingshu Jiang, Xuemei Wang, Fan Cao, Rui Zhang, Zhaihua Liu, Xingang Hu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bao LiuDepartment of Respiratory and Critical Care Medicin, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, China.
Haoran ChiInstitute of Basic Theory of Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
Tingshu JiangDepartment of NO.2 Pulmonology, Yantai Yuhuangding Hospital, Yantai, China.
Xuemei WangDepartment of Traditional Chinese Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, China.
Fan CaoDepartment of Pulmonology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, China.
Rui ZhangDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Zhaihua LiuInstitute of Basic Theory of Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
Xingang HuDepartment of Respiratory and Critical Care Medicin, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with limited therapeutic options and a poor prognosis. Here, we identify the nuclear receptor NR4A1 as a pivotal mediator of estrogen's antifibrotic effects through its regulation of TGF-β signaling. Clinical analysis revealed increased expression of NR4A1 and estrogen receptor α (ERα) in IPF lung tissues, with NR4A1 phosphorylation correlating with disease progression. Mechanistic investigations demonstrated that sustained TGF-β signaling induces NR4A1 phosphorylation, impairing its negative feedback regulation of fibrosis. Estrogen, acting via ERα, restored NR4A1 activity by suppressing phosphorylation, thereby reducing fibrosis both

Indexed as

Cell biologyMolecular biology

Identifiers

PMID41767264
PMCPMC12936828

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.