ArticleHealth science reports2026
A Comparative Study on the Effect of PRP in Healing Diabetic Foot Ulcers Compared to Standard Treatment in Diabetic Patients: A Randomized Clinical Trial Study.
Article in Health science reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Beyond Short-Term Healing: A Call for Long-Term and Economic Evaluation of PRP in Diabetic Foot Ulcer Management.Health science reports · 2026Article
- Regenerative Therapies for Cosmetic Dermatology for Patients with Diabetes Mellitus: Skin Aging, Aesthetic Concerns, and Evidence-Based Best Practices.International journal of molecular sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aims: Emerging therapies such as autologous platelet-rich plasma (PRP), which delivers a supraphysiological concentration of growth factors including but not limited to PDGF, VEGF, and TGF-β have shown promise in enhancing tissue regeneration and healing. This study compares two treatments for diabetic foot ulcers: the standard method (normal saline washing and routine debridement) and the PRP method (autologous platelet-rich plasma). It evaluates PRP's effectiveness in accelerating healing compared to standard care in diabetic patients, specifically in terms of wound area reduction over a 6-week period, the proportion of patients achieving complete healing, and the average time to healing. Methods: In this double-blind randomized clinical trial conducted on patients referred to Velayat Hospital, 50 eligible type I and II diabetic patients aged 40-70 were randomly allocated to two groups using color-coded sealed envelopes, ensuring allocation concealment. One group received PRP and the other standard treatment. Double-blinding was maintained by using identical syringes for both treatments, and independent assessors unaware of group assignments evaluated wound healing weekly. Results: There was no significant difference between the two groups regarding gender and HbA1c levels. However, a significant difference was observed in wound healing rates between the PRP method and the standard method across the two groups. Additionally, a meaningful relationship was found when comparing the average age of patients treated with both methods. There was no significant difference between the two groups regarding gender and HbA1c levels. Conclusions: Ultimately, our research indicates that the PRP method is a more effective alternative to the standard method alone for the treatment of diabetic foot ulcers. Additionally, younger patients demonstrated a faster rate of diabetic foot ulcer healing. PRP's superior efficacy may justify its moderate upfront costs given potential long-term savings from reduced complications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.