ReviewFrontiers in endocrinology2026
Role of metabolic reprogramming and lactylation in diabetic nephropathy: molecular mechanisms and therapeutic prospects - a narrative review.
Review in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetic nephropathy (DN) remains challenging to halt completely despite standard therapies. Beyond being a glycolytic byproduct, lactate can act as a signaling metabolite and a substrate for lysine lactylation, linking metabolic reprogramming to chromatin regulation. To summarize the lactate-lactylation axis in DN and its translational implications, we conducted a narrative review by searching PubMed, Web of Science, and Scopus for English-language studies up to October 2025 using terms related to DN, metabolic reprogramming, glycolysis, lactate, and lactylation. Evidence was prioritized from DN/kidney studies, with selected mechanistic reports from related contexts included when relevant. The results show that hyperglycemia, hypoxia, and inflammation promote a shift toward glycolysis, leading to lactate accumulation, mitochondrial dysfunction, and inflammatory signaling in DN. Lactate-associated histone and non-histone lactylation has been implicated in cell-type-dependent transcriptional programs across tubular epithelial cells, podocytes, endothelial cells, and immune cells, potentially amplifying inflammation and fibrosis. Candidate "writers/erasers" and emerging non-canonical lactyltransferase activities suggest lactylation may represent a tunable epigenetic node. Thus, the lactate-lactylation axis provides a promising but evolving framework for DN pathogenesis and therapy. Future work should prioritize DN-focused validation, including studies using human DN samples where feasible, standardized detection, and stage- and cell-specific interventions to minimize systemic metabolic disruption.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.