Evidence map›Paper›PMID 41767413›Full record

ArticleBioMed research international2026

Nitric Oxide Synthase 2 (NOS2) Gene Polymorphisms Association With Risk of Pulmonary Tuberculosis (PTB): A Case-Control Study.

Ebrahim Alijani, Mahboobeh Sabeti Akbar-Abad, Hossein Shahriari, Fatemeh Keykha, Mahdi Majidpour, Michael Faqih, Mohsen Taheri, Mahdi Atabaki

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In one paragraph

Article in BioMed research international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ebrahim AlijaniClinical Immunology Research Center, Zahedan University of Medical Sciences, Zahedan, Iran, zaums.ac.ir.ORCID https://orcid.org/0000-0001-9921-8947
Mahboobeh Sabeti Akbar-AbadDepartment of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran, zaums.ac.ir.ORCID https://orcid.org/0000-0001-7587-6646
Hossein ShahriariClinical Immunology Research Center, Zahedan University of Medical Sciences, Zahedan, Iran, zaums.ac.ir.ORCID https://orcid.org/0000-0003-4323-888X
Fatemeh KeykhaDepartment of Biology, Faculty of Science, University of Sistan and Baluchestan, Zahedan, Iran, usb.ac.ir.ORCID https://orcid.org/0009-0002-6397-7372
Mahdi MajidpourDepartment of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran, zaums.ac.ir.ORCID https://orcid.org/0000-0002-3696-6953
Michael FaqihStudent Research Committee, Zahedan University of Medical Sciences, Zahedan, Iran, zaums.ac.ir.ORCID https://orcid.org/0009-0007-2803-1131
Mohsen TaheriGenetics of Non-Communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran, zaums.ac.ir.ORCID https://orcid.org/0000-0002-1110-4417
Mahdi AtabakiClinical Immunology Research Center, Zahedan University of Medical Sciences, Zahedan, Iran, zaums.ac.ir.ORCID https://orcid.org/0000-0002-6875-3311

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Pulmonary tuberculosis (PTB) remains a significant global health challenge, necessitating a deeper understanding of genetic factors influencing susceptibility. This study investigates the association between five specific polymorphisms in the nitric oxide synthase 2 (NOS2) genes (rs7215373, rs2297518, rs2274894, rs1800482, and rs9282799) and the risk of developing PTB. Methods: Utilizing a case-control design, we analyzed genetic samples from 150 PTB patients and 150 matched healthy controls. Genotyping was conducted using amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) methods. Statistical analyses, including logistic regression and Hardy-Weinberg equilibrium tests, were performed to assess the associations between NOS2 polymorphisms and PTB risk. Results: Our findings indicate that the rs7215373 and rs2274894 polymorphisms had no significant association with the risk of PTB. rs2297518 in the allelic model significantly reduced the risk by 0.50 against the occurrence of PTB ( Conclusion: These results suggest that specific NOS2 gene polymorphisms may play a role in modulating the immune response to

Indexed as

Genetic Predisposition to DiseaseNitric Oxide Synthase Type IIPolymorphism, Single NucleotideTuberculosis, PulmonaryAdultAllelesCase-Control StudiesFemaleGene FrequencyGenetic Association StudiesGenotypeHumansMaleMiddle AgedRisk FactorsNitric Oxide Synthase Type IINOS2 protein, humannitric oxide synthase 2 (NOS2)polymorphismpulmonary tuberculosis (PTB)

Identifiers

PMID41767413
PMCPMC12935765

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.