SynthesisFrontiers in medicine2026
Diabetes mellitus is associated with an increased risk of postoperative neurocognitive disorders: a systematic review.
Synthesis in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Diabetes mellitus (DM) is increasingly recognized as an independent risk factor for perioperative neurocognitive disorders (PND). The rising global incidence of DM, projected to affect over 783 million people by 2045, necessitates a deeper understanding of its implications for surgical outcomes. Methods: This review conducted a bibliometric analysis of 182 studies indexed in the Web of Science, focusing on the relationship between DM and PND. A systematic search was performed across multiple electronic databases, including PubMed and The Cochrane Library, to identify relevant articles published up to November 2024. Results: The analysis revealed that DM significantly increases the risk of PND, particularly POD, with studies indicating a 1.84-fold increased risk of POCD in diabetic patients. Key mechanisms identified include vascular brain injury, impaired glucose metabolism, inflammation, and oxidative stress. Notably, countries such as China, the USA, and Germany are leading research efforts in this area, highlighting a global interest in understanding these associations. Conclusion: Further research is needed to elucidate causal mechanisms between DM and PND. Enhanced understanding of these mechanisms may inform targeted interventions to mitigate the risk of cognitive decline in diabetic patients undergoing surgery, ultimately improving patient outcomes and reducing healthcare burdens.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.