Evidence map›Paper›PMID 41767597›Full record

ReviewResearch (Washington, D.C.)2026

RNA on Display: Cell Surface RNA as a Novel Layer of Cellular Regulation.

Serina Chahal, Pious Jose, Adam Greasley, Kevin Vytlingam, Raj Kumar Thapa, Hayley Pyne, Amal Abu Omar, Xiufen Zheng

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Research (Washington, D.C.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Serina ChahalDepartment of Microbiology and Immunology, Western University, London, ON, Canada.ORCID https://orcid.org/0000-0003-0938-1666
Pious JoseDepartment of Pathology and Laboratory Medicine, Western University, London, ON, Canada.
Adam GreasleyDepartment of Pathology and Laboratory Medicine, Western University, London, ON, Canada.
Kevin VytlingamDepartment of Pathology and Laboratory Medicine, Western University, London, ON, Canada.
Raj Kumar ThapaDepartment of Surgery, Western University, London, ON, Canada.ORCID https://orcid.org/0000-0002-7439-6760
Hayley PyneDepartment of Microbiology and Immunology, Western University, London, ON, Canada.
Amal Abu OmarDepartment of Surgery, Western University, London, ON, Canada.
Xiufen ZhengDepartment of Microbiology and Immunology, Western University, London, ON, Canada.ORCID https://orcid.org/0000-0001-9988-697X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

RNA has been established as an essential molecule in virtually all cellular processes. Besides its role in cellular modulation via extracellular vesicular release, it has long been thought to only exert its function intracellularly. Recent discoveries have shown evidence of extracellular RNA tethered to the cell surface of different cell types. These cell surface RNAs are predominantly modified with sialylated glycans, denominating them cell surface glycoRNAs. While the expression of cell surface glycoRNAs has been found on a wide array of immune cell and cancer cell types, research on its functional roles has only recently been explored due to challenges in detection, isolation, and sequencing of this new subclass of RNA. In this review, the history, biogenesis, detection and isolation techniques, and functional roles of cell surface RNA to date will be discussed, in addition to commenting on its translational capacity for studying immunomodulation and disease. Acknowledging the presence of cell surface RNAs and propelling our understanding on their function will provide a new avenue to study cellular modulation and cell-cell communication.

Identifiers

PMID41767597
PMCPMC12946384

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.