Evidence map›Paper›PMID 41767601›Full record

ArticleResearch (Washington, D.C.)2026

The Influence of Sleep and Diet on Human Peripheral Immunity and Chronic Health Conditions.

Yiran Zhao, Wenran Li, Bingjie Li, Siyu Zhou, Xianlei Zhao, Qi Wang, Yingyu Cheng, Yali Luo, Jingxuan Han, Xuling Han and 20 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Research (Washington, D.C.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Yiran ZhaoHuman Phenome Institute, Huadong Hospital, Fudan University, Shanghai 201203, China.
Wenran LiShanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Bingjie LiShanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Siyu ZhouHuman Phenome Institute, Huadong Hospital, Fudan University, Shanghai 201203, China.
Xianlei ZhaoHuman Phenome Institute, Huadong Hospital, Fudan University, Shanghai 201203, China.
Qi WangHuman Phenome Institute, Huadong Hospital, Fudan University, Shanghai 201203, China.
Yingyu ChengShanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Yali LuoHuman Phenome Institute, Huadong Hospital, Fudan University, Shanghai 201203, China.
Jingxuan HanHuman Phenome Institute, Huadong Hospital, Fudan University, Shanghai 201203, China.
Xuling HanHuman Phenome Institute, Huadong Hospital, Fudan University, Shanghai 201203, China.
Helian LiHuman Phenome Institute, Huadong Hospital, Fudan University, Shanghai 201203, China.
Jian GaoHuman Phenome Institute, Huadong Hospital, Fudan University, Shanghai 201203, China.
Jialin ZhaoHuman Phenome Institute, Huadong Hospital, Fudan University, Shanghai 201203, China.
Zhonghan SunHuman Phenome Institute, Huadong Hospital, Fudan University, Shanghai 201203, China.
Mengmeng KongHuman Phenome Institute, Huadong Hospital, Fudan University, Shanghai 201203, China.
Xiaofeng ZhouHuman Phenome Institute, Huadong Hospital, Fudan University, Shanghai 201203, China.
Ying YuHuman Phenome Institute, Huadong Hospital, Fudan University, Shanghai 201203, China.
Wanwan HouHuman Phenome Institute, Huadong Hospital, Fudan University, Shanghai 201203, China.
Qinsheng ChenHuman Phenome Institute, Huadong Hospital, Fudan University, Shanghai 201203, China.
Jingxian ZhangHuman Phenome Institute, Huadong Hospital, Fudan University, Shanghai 201203, China.
Xiaofeng WangHuman Phenome Institute, Huadong Hospital, Fudan University, Shanghai 201203, China.
Jingchun LuoHuman Phenome Institute, Huadong Hospital, Fudan University, Shanghai 201203, China.
Li JinState Key Laboratory of Genetics and Development of Complex Phenotypes, School of Life Sciences, Human Phenome Institute, and Zhongshan Hospital, Fudan University, Shanghai 200438, China.
Leming ShiInstitute of Immunophenome, International Human Phenome Institutes (Shanghai), Shanghai 200438, China.
Yan ZhengState Key Laboratory of Genetics and Development of Complex Phenotypes, School of Life Sciences, Human Phenome Institute, and Zhongshan Hospital, Fudan University, Shanghai 200438, China.
Human Phenome Project Technological Consortium
Human Phenome Project Scientific Consortium
Huiru TangState Key Laboratory of Genetics and Development of Complex Phenotypes, School of Life Sciences, Human Phenome Institute, and Zhongshan Hospital, Fudan University, Shanghai 200438, China.
Sijia WangShanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Feng QianHuman Phenome Institute, Huadong Hospital, Fudan University, Shanghai 201203, China.ORCID https://orcid.org/0000-0002-2312-5936

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exposures that disrupt the immune system can affect human health. This study aimed to understand immune variability influenced by exposures from the perspectives of systems biology and multiomics. We recruited 1,001 healthy participants and collected 183 exposures, 1,332 immunophenotypes, whole blood transcriptome, and plasma metabolome. Through exposure-immune wide association analysis, we identified 81 significant signals, with sleep and diet emerging as dominant exposures affecting the immunity. Sleep and diet influence the proportions of innate immune cells and the expression levels of immune cell surface proteins such as CD85j and CD16, respectively. Notably, distinct from the increase in interleukin-1β secretion caused by short-term late sleep onset, long-term late sleep onset triggered chronic inflammation with more metabolic changes. On the basis of the intracorrelation structure of exposure data, composite exposures were constructed and were found to have additional effects on immunophenotypes. Bidirectional mediation analysis revealed that sleep effects on immunity are commonly linked to the transcriptome, whereas dietary influences on immunity are primarily associated with the metabolome. We quantified the mediation effects of exposures, omics, and immunophenotypes and further demonstrated that these effects reflect human immune health or chronic diseases. Our study drew a comprehensive map of "exposure-immunome-omics" and is expected to provide guidance for future health assessment and management.

Identifiers

PMID41767601
PMCPMC12943795

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.