Evidence map›Paper›PMID 41767625›Full record

ArticleGastroenterology report2026

Physical activity, sedentary behaviour, and exocrine and endocrine pancreatic diseases: results from a prospective cohort study and Mendelian randomization.

Tianyi Che, Zhipeng Wu, Shenglan You, Xixian Ruan, Lintao Dan, Yao Zhang, Susanna C Larsson, Xiaoyan Wang, Jie Chen, Chunhua Zhou

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Article in Gastroenterology report, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Tianyi CheDepartment of Gastroenterology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P. R. China.
Zhipeng WuDepartment of Gastroenterology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P. R. China.
Shenglan YouDepartment of Gastroenterology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P. R. China.
Xixian RuanDepartment of Gastroenterology, The Third Xiangya Hospital, Central South University, Changsha, P. R. China.ORCID https://orcid.org/0000-0002-4937-9168
Lintao DanDepartment of Gastroenterology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P. R. China.ORCID https://orcid.org/0000-0001-5963-2772
Yao ZhangDepartment of Gastroenterology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P. R. China.
Susanna C LarssonUnit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Xiaoyan WangDepartment of Gastroenterology, The Third Xiangya Hospital, Central South University, Changsha, P. R. China.
Jie ChenDepartment of Gastroenterology, The Third Xiangya Hospital, Central South University, Changsha, P. R. China.
Chunhua ZhouDepartment of Gastroenterology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P. R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Whether physical activity and restricted sedentary behaviour can maintain pancreas health remains inconclusive. We aimed to comprehensively investigate the associations of physical activity and sedentary behaviour with exocrine and endocrine pancreatic diseases in a prospective cohort study and further verify these associations by using Mendelian randomization (MR). Methods: The prospective study included 437,131 UK Biobank participants free of pancreatic diseases at baseline. We used moderate-to-vigorous physical activity (MVPA) to indicate physical activity and leisure screen time (LST) to indicate sedentary behaviour. Outcomes included five diseases related to pancreatic secretory functions. We conducted Cox proportional hazards regression and mediation analyses to examine the mediating role of body mass index (BMI). MR analysis was used to assess the robustness of the observational findings. Results: During a mean follow-up of 14 years, we identified 2,548 acute pancreatitis (AP), 638 chronic pancreatitis (CP), 1,711 pancreatic cancer (PC), 1,705 type 1 diabetes mellitus (T1DM), and 19,371 type 2 diabetes mellitus (T2DM) cases. Increasing MVPA was associated with AP, CP, T1DM, and T2DM risk in a U-shaped manner, with the lowest risk at ∼3,000 metabolic equivalent tasks-minutes/week (all Conclusion: Moderate MVPA and strict restriction of LST can serve as effective and practical strategies for preventing AP, CP, and T2DM.

Indexed as

acute pancreatitischronic pancreatitisdiabetes mellituspancreatic cancerphysical activitysedentary behaviour

Identifiers

PMID41767625
PMCPMC12947578

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.