ArticleExperimental and therapeutic medicine2026
Analysis of independent prognostic factors for the occurrence and severity of heart failure after chemotherapy in patients with small cell lung cancer.
Article in Experimental and therapeutic medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients with small cell lung cancer (SCLC) may develop heart failure after chemotherapy; therefore, it is crucial to explore the factors that affect the occurrence of heart failure. The present study retrospectively collected data from 550 patients with SCLC who received chemotherapy. Analysis of differences between groups (patients with and without heart failure, as well as patients with different severities of heart failure) was performed on demographic characteristics and cardiac biomarkers, followed by multivariate and multinomial logistic regression analyses on factors that were found to be significantly different in the intergroup analysis, to screen for factors that significantly influence heart failure. Finally, receiver operating characteristic (ROC) curve analysis was performed to assess the predictive ability of combined indicators for the occurrence and severity of heart failure. Multivariate logistic regression analysis initially identified the cumulative dose of chemotherapy drugs, cardiac troponin I (cTnI), N-terminal pro-B-type natriuretic peptide, left ventricular ejection fraction (LVEF) and creatine kinase-myocardial band as independent prognostic factors of heart failure. Multinomial logistic regression analysis showed that both cTnI and LVEF had significant effects in predicting the severity of heart failure. ROC curve analysis demonstrated that a cTnI level ≥0.044 ng/ml and LVEF ≤39.083% could predict the occurrence of heart failure, whereas a cTnI level ≥0.059 ng/ml and LVEF ≤37.216% were associated with moderate-to-severe heart failure. The standardized combination indicators (cTnI and LVEF) also showed strong predictive ability (AUC >0.75). In conclusion, the present study demonstrated that cTnI, LVEF and their combination may serve as independent prognostic factors for predicting the occurrence and severity of heart failure in patients with SCLC after chemotherapy. These findings suggest that cTnI and LVEF should be routinely monitored during the early stages of chemotherapy for identifying patients at high risk for heart failure and early intervention, ultimately improving patient prognosis.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.