Evidence map›Paper›PMID 41767677›Full record

ArticleFrontiers in veterinary science2026

Lysine lactylation regulates ATF4-mediated stress responses under glucose starvation in canine hemangiosarcoma.

Tamami Suzuki, Kazuki Heishima, Jumpei Yamazaki, Masaya Yamazaki, Ryohei Kinoshita, Sangho Kim, Kenji Hosoya, Yuko Okamatsu-Ogura, Michihito Sasaki, Peng Xu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in veterinary science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Tamami SuzukiLaboratory of Comparative Pathology, Department of Clinical Sciences, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.
Kazuki HeishimaThe United Graduate School of Drug Discovery and Medical Information Sciences, School of Medicine, Gifu University, Gifu, Japan.
Jumpei YamazakiTranslational Research Unit, Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.
Masaya YamazakiDivision of Carcinogenesis, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan.
Ryohei KinoshitaCancer Research Unit, One Health Research Center, Hokkaido University, Sapporo, Hokkaido, Japan.
Sangho KimCancer Research Unit, One Health Research Center, Hokkaido University, Sapporo, Hokkaido, Japan.
Kenji HosoyaCancer Research Unit, One Health Research Center, Hokkaido University, Sapporo, Hokkaido, Japan.
Yuko Okamatsu-OguraLaboratory of Biochemistry, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.
Michihito SasakiDivision of Molecular Pathobiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Hokkaido, Japan.
Peng XuDepartment of Pathology, Yale School of Medicine, New Haven, CT, United States.
Qin YanDepartment of Pathology, Yale School of Medicine, New Haven, CT, United States.
Takashi KimuraLaboratory of Comparative Pathology, Department of Clinical Sciences, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.
Keisuke AoshimaLaboratory of Comparative Pathology, Department of Clinical Sciences, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Excess lactate is produced in tumor cells by aerobic glycolysis and regulates gene expressions by histone lactylation. However, how histone lactylation functions under glucose-limited conditions remains unknown. Here, we show that lysine lactylation redistributes to transcription start sites (TSSs) during glucose deprivation, thereby altering biological behaviors in canine hemangiosarcoma (HSA) cells. Glucose deprivation significantly decreased global histone lactylation levels, while lactylation peaks were enriched at TSSs of ATF4-regulated stress-response, asparagine-synthesis and immune-related genes. Stress-response gene expressions were upregulated, and ATF4 polyclonal knockout abrogated this activation. [U-

Indexed as

dogglucosehemangiosarcomahistone lactylationstress responsetumor metabolism

Identifiers

PMID41767677
PMCPMC12936438

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.