Evidence map›Paper›PMID 41767714›Full record

ArticleNeuroImmune pharmacology and therapeutics2026

Analyses of astrocyte-neuron lactate shuttle transporter levels in brain tissues from people with HIV-associated neurocognitive impairment and Alzheimer's disease.

Ali Boustani, Anna Laird, Leeann Shu, Erin E Sundermann, David J Moore, Robert Rissman, Jerel A Fields

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImmune pharmacology and therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ali BoustaniDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Anna LairdDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Leeann ShuDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Erin E SundermannDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
David J MooreDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Robert RissmanAlzheimer's Therapeutic Research Institute, Keck School of Medicine, University of Southern California, San Diego, CA, USA.
Jerel A FieldsDepartment of Psychiatry, University of California San Diego, 9500 Gilman Dr., La Jolla, CA, 92093, USA.

Funding

Cannabis and Pathogenic Mechanisms influencing Blood Brain Barrier Function in HIVR01DA058405 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jerel Adam Fields, Jennifer E Iudicello · 2023 to 2026
$5.0M
The role of TFAM alterations in HIV- and ART-induced mitochondrial dysfunction in the brainR01MH128108 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jerel Adam Fields · 2022 to 2026
$2.3M
The role of TREM2 in Alzheimer's disease related neuropathogenesis in people with HIVR01AG092255 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jerel Adam Fields · 2025 to 2026
$1.5M
Disentangling the HIV/opioid intertwined mechanisms on mitochondrial mediated inflammasome activation, neurotoxicity and targeting strategies: In vivo and in vitro analyses of fresh human brainR01DA062278 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Antoine Chaillon, Jerel Adam Fields · 2025 to 2026
$1.5M
NIA NIH HHS R01 AG092255NIDA NIH HHS R01 DA058405NIDA NIH HHS R01 DA062278NIMH NIH HHS R01 MH128108
6 · The paper itself

Abstract

Objectives: With the success of antiretroviral therapy (ART), people with HIV (PWH) are living longer. As they age, they increasingly face age-related comorbidities, including neurodegenerative conditions. The astrocyte-neuron lactate shuttle (ANLS) is a key mechanism that couples astrocytic glycolysis to neuronal oxidative metabolism, ensuring an adequate energy supply for synaptic activity. Disruption of this system has been implicated in both Alzheimer's disease (AD) and HIV-associated neurocognitive impairment (HIV-NCI), conditions characterized by some overlapping cognitive deficits yet distinct pathological drivers. Methods: We investigated the expression of major ANLS transporters, including glucose transporters (GLUT1, GLUT3) and monocarboxylate transporters (MCT1, MCT2, MCT4), in postmortem frontal cortex from individuals with AD and PWH. There were two HIV cohorts based on viral suppression (suppressed/non-suppressed), and both were stratified by neurocognitive status (neurocognitively normal/neurocognitively impaired), while AD participants were compared to cognitively healthy participants. Quantitative immunoblotting and immunofluorescence imaging characterized disease-specific alterations. Results: In AD, both endothelial (GLUT1 Conclusions: These findings identify shared and distinct patterns of metabolic disruption: degeneration-driven ANLS failure in AD versus inflammation-driven uncoupling in HIV-NCI.

Indexed as

Alzheimer’s diseaseastrocyte-neuron lactate shuttleHIV-associated NCIneurocognitive impairment

Identifiers

PMID41767714
PMCPMC12945393

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.