ArticleBrain, behavior, & immunity - health2026
Linking peripheral low-grade inflammation and blood-cerebrospinal fluid barrier leakage in schizophrenia spectrum disorders - A retrospective analysis.
Article in Brain, behavior, & immunity - health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Social impairments and low-grade inflammation (LGI) are associated with psychotic disorders (e.g. schizophrenia spectrum disorders). Social impairments are important symptoms of the disease nonetheless a disturbed social interaction and inflammatory processes are further discussed as being part of the underlying pathophysiology, which is also characterized by blood-cerebrospinal fluid barrier (BCSFB) dysfunction. The relationship between social impairments, peripheral LGI (pLGI) and BCSFB permeability in psychotic disorders, however, is poorly understood. Therefore, we hypothesized that social impairment might be linked to pLGI, which, in turn, might affect BCSFB function in schizophrenia. Method: We conducted a retrospective chart review of all psychiatric inpatients who underwent lumbar puncture as part of their diagnostic work-up between January 1, 2021, and June 30, 2023 (n = 53). Thirty-one patients diagnosed with SSD (n = 27) or affective psychosis (n = 4) with a C-reactive protein (CRP) serum level <10 mg/L upon admission, indicating the absence of acute inflammation, were included in the analysis. Results: The cerebrospinal fluid (CSF)/serum albumin ratio - as a measure of BCSFB permeability - was shown to be positively correlated with our measure of pLGI (r = 0.418, p = 0.019) using the pLGI score (previously also named "INFLA-score", "LGI score"), as well as with age (r = 0.415, p = 0.020) . Additionally, a trend toward a negative correlation with global functioning (GAF) was observed (r = -0.349, p = 0.054).A multiple linear regression including pLGI, age, and sex yielded the best-fitting model (p = 0.003, corrected R Conclusion: These data demonstrate - for the first time - a link between an established peripheral marker of LGI and BCSFB permeability in schizophrenia. Platelets were found to be the main driver of the pLGI score regarding BCSFB permeability. Future research will need to replicate these findings and could explore whether measures of peripheral inflammation could be useful in the diagnostic work-up of patients with psychotic disorders.
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