ArticleChemical science2026
Molecular basis for the biosynthetic divergence of anthracyclines kosinostatin and chartreusin.
Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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11 authors.
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Abstract
Kosinostatin and chartreusin are both anthracycline-type antitumor agents. The structure of kosinostatin incorporates a spirally fused pyrrolopyrrole moiety attached to a five-membered ring of its anthraquinone core, whereas chartreusin possesses a distinct, rearranged pentacyclic aromatic dilactone aglycone. Biosynthetic divergence in kosinostatin and chartreusin is governed by highly homologous proteins, KstA15 and ChaU, which catalyze phenol hydroxylation and hydration, respectively. In this report, we successfully engineered a functional swap between ChaU and KstA15
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