Evidence map›Paper›PMID 41767915›Full record

ArticleBiomedical optics express2025

Four-modal device comprising optical coherence tomography, photoacoustic tomography, ultrasound, and Raman spectroscopy developed for in vivo skin lesion assessment.

Anatoly Fedorov Kukk, Di Wu, Rüdiger Panzer, Steffen Emmert, Bernhard Roth

Abstract read
In one paragraph

Article in Biomedical optics express, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Anatoly Fedorov KukkHannover Centre for Optical Technologies, Leibniz University Hannover, Nienburger Straße 17, 30167 Hannover, Germany.
Di WuHannover Centre for Optical Technologies, Leibniz University Hannover, Nienburger Straße 17, 30167 Hannover, Germany.ORCID https://orcid.org/0000-0001-5919-7010
Rüdiger PanzerClinic and Policlinic for Dermatology and Venereology, University Medical Center Rostock, Strempelstraße 13, 18057 Rostock, Germany.
Steffen EmmertClinic and Policlinic for Dermatology and Venereology, University Medical Center Rostock, Strempelstraße 13, 18057 Rostock, Germany.
Bernhard RothHannover Centre for Optical Technologies, Leibniz University Hannover, Nienburger Straße 17, 30167 Hannover, Germany.ORCID https://orcid.org/0000-0001-9389-7125

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The accurate determination of the depth of the infiltration and the pathophysiology is critical to the treatment and excision of skin cancer, particularly melanoma. The current gold standard in skin cancer diagnostics comprises skin biopsy followed by histological examination, which is invasive, time-consuming, and limited in measuring at the deepest level. Non-invasive imaging techniques like dermoscopy, confocal microscopy, and multiphoton microscopy also face limitations in accurately capturing contrast and depth information across lesion locations or distinguishing between malignant and benign tissue. Thus, there is a need for non-invasive techniques capable of obtaining 3D images of skin lesions with sufficiently high spatial resolution, which at the same time assess pathophysiology. To address this problem, we have developed a device that combines optical coherence tomography (OCT), photoacoustic tomography, ultrasound, and Raman spectroscopy into a single scanning unit, enabling the

Identifiers

PMID41767915
PMCPMC12945489

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.