Analysis of the key signaling pathway of baicalin that induces autophagy in papillary thyroid cancer via an optical resonator.

Yi Lai, Dan Ru, Chenhuan Ding, Chen Wang, Ling Ding, Cenxin Luo, Yujie Qi, Xianfeng Chen, Hailang Dai, He Li

Abstract read

In one paragraph

Article in Biomedical optics express, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in

0citing papers in PubMed

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Yi LaiDepartment of Traditional Chinese Medicine, Department of Head and Neck Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, No. 160 Pujian Road, Shanghai 200127, China.

Dan RuDepartment of Traditional Chinese Medicine, Department of Head and Neck Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, No. 160 Pujian Road, Shanghai 200127, China.

Chenhuan DingDepartment of Traditional Chinese Medicine, Department of Head and Neck Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, No. 160 Pujian Road, Shanghai 200127, China.

Chen WangDepartment of Traditional Chinese Medicine, Department of Head and Neck Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, No. 160 Pujian Road, Shanghai 200127, China.

Ling DingDepartment of Traditional Chinese Medicine, Department of Head and Neck Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, No. 160 Pujian Road, Shanghai 200127, China.

Cenxin LuoDepartment of Traditional Chinese Medicine, Department of Head and Neck Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, No. 160 Pujian Road, Shanghai 200127, China.

Yujie QiSchool of Physics and Astronomy, Shanghai Jiao Tong University, No. 800 Dongchuan Road, Shanghai 200240, China.

Xianfeng ChenSchool of Physics and Astronomy, Shanghai Jiao Tong University, No. 800 Dongchuan Road, Shanghai 200240, China.

Hailang DaiSchool of Physics and Astronomy, Shanghai Jiao Tong University, No. 800 Dongchuan Road, Shanghai 200240, China.ORCID https://orcid.org/0000-0002-1301-7448

He LiDepartment of Traditional Chinese Medicine, Department of Head and Neck Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, No. 160 Pujian Road, Shanghai 200127, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite advances in cancer therapy, high mortality persists due to drug resistance and relapse. Developing selective anticancer agents with minimal toxicity and resistance remains crucial. Baicalin shows antitumor potential, but its mechanism against papillary thyroid carcinoma (PTC) remains unclear. We designed an optical resonator to monitor baicalin-membrane protein interactions, identifying NGFR as the key ATR-shifted target. Mechanistic studies revealed baicalin induces autophagy via the NGFR/MAPK/mTOR axis, validated through in vitro and in vivo models. These findings position baicalin as a promising PTC therapeutic with clinical translation potential.

Identifiers

PMID41767921

DOI10.1364/BOE.561007

PMCPMC12945545

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.