Evidence map›Paper›PMID 41767933›Full record

ArticleBiomedical optics express2025

Towards noninvasive white blood cell count.

Arutyun Bagramyan, Juwell W Wu, Kamdin Mirsanaye, Clemens Alt, Charles P Lin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Arutyun BagramyanCenter for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Juwell W WuCenter for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Kamdin MirsanayeCenter for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Clemens AltCenter for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Charles P LinCenter for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite rapid advances in diagnostic and imaging technologies, no clinical device for noninvasive monitoring of the immune system is currently available. The standard white blood cell count (WBCC), a key clinical measure for assessing patients' health, requires drawing blood, which poses inherent risks for secondary infection and anemia in vulnerable patient populations. In addition, the specialized equipment, expertise, and infrastructure are not always available in resource-poor settings. We present a method for noninvasive and label-free WBCC by imaging human oral mucosa using a miniaturized oblique back-illumination microscope (mOBM), together with an analytical pipeline for cell detection and quantification. In a pilot study involving 34 healthy subjects, we validated the ability of our system to detect and quantify circulating leukocytes and compared our image-based WBCCs with standard laboratory measurements. The ability to perform noninvasive WBCC will enable real-time assessment of immune status during infection and inflammation or in response to therapeutic intervention without repetitive blood sampling.

Identifiers

PMID41767933
PMCPMC12945479

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.