Evidence map›Paper›PMID 41768529›Full record

ReviewNeuroscience applied2026

Long non-coding RNAs and accelerated aging in bipolar disorder.

Sultan Ekinci, Hidayet Ece Arat Çelik, İbrahim Fettahoğlu, Alessio Squassina, Deniz Ceylan

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuroscience applied, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sultan EkinciSuruç State Hospital, Republic of Türkiye Ministry of Health, Şanlıurfa, Turkey.
Hidayet Ece Arat ÇelikDepartment of Psychiatry, School of Medicine, Maltepe University, İstanbul, Turkey.
İbrahim FettahoğluKoç University Center of Translational Medicine (KUTTAM), Istanbul, Turkey.
Alessio SquassinaSection of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Deniz CeylanKoç University Center of Translational Medicine (KUTTAM), Istanbul, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bipolar disorder (BD) has been associated with accelerated biological aging, potentially driven by genetic and environmental factors. Long non-coding RNAs (lncRNAs), key regulators of epigenetic, telomere attrition, and cellular aging processes, may play a role in accelerated aging in BD. This review summarizes current evidence on aging-associated lncRNAs and their relevance to BD. We searched PubMed for English-language original studies published up to June 2, 2025, using keywords related to lncRNAs, aging-related mechanisms, and aging-associated neuropsychiatric disorders. A total of 112 articles reported 163 lncRNAs, of which 19 were common to aging-related mechanisms and aging-associated neuropsychiatric disorders. Among these, ANRIL, HOTAIR, TUG1, MALAT1, NEAT1, and GAS5 have been reported in both aging-related contexts and BD; however, their relevance to BD requires further confirmation in independent and well-characterized cohorts. The remaining overlapping lncRNAs may represent additional candidates of interest for future investigation rather than established contributors to BD pathophysiology.

Indexed as

Accelerated agingAging-associated neuropsychiatric disordersBipolar disorderLong non-coding RNAs

Identifiers

PMID41768529
PMCPMC12945652

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.