Evidence map›Paper›PMID 41768653›Full record

ArticleACS omega2026

Enhanced Anticancer Activity of Ibuprofen and 2'-Hydroxy-2,3,5'-trimethoxychalcone-Linked Polymeric Micelles in HeLa Cells.

Suji Baek, Chang-Whan Yoon, Kang Pa Lee, Bo Hyun Kim, Ewon Jung, Jangok Yeo, Sang-Hyuk Lee, Myeong Sik Yoon

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Suji BaekResearch and Development Center, UMUST R&D Corporation, 84, Madeul-ro 13-gil, Dobong-gu, Seoul 01411, Korea.
Chang-Whan YoonDepartment of Otorhinolaryngology-Head and Neck Surgery, Sungkyunkwan University School of Medicine, Kangbuk Samsung Hospital, Seoul 03181, Korea.ORCID https://orcid.org/0009-0009-5940-3430
Kang Pa LeeResearch and Development Center, UMUST R&D Corporation, 84, Madeul-ro 13-gil, Dobong-gu, Seoul 01411, Korea.
Bo Hyun KimNucleic Acid Therapeutics Research Center, Korea Research Institute of Bioscience & Biotechnology, Cheongju, Chungbuk 28116, Korea.
Ewon JungDepartment of Pharmaceutical Engineering, Hoseo University, Asan, Chungnam 31499, Korea.
Jangok YeoDepartment of Otorhinolaryngology, Eulji University Hospital, Eulji University College of Medicine, Daejeon 35233, Korea.ORCID https://orcid.org/0009-0002-5577-9624
Sang-Hyuk LeeDepartment of Otorhinolaryngology-Head and Neck Surgery, Sungkyunkwan University School of Medicine, Kangbuk Samsung Hospital, Seoul 03181, Korea.
Myeong Sik YoonDepartment of Pharmaceutical Engineering, Hoseo University, Asan, Chungnam 31499, Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cervical cancer (CVC) remains one of the most prevalent gynecological malignancies, necessitating the development of more effective therapeutic strategies to reduce tumor burden and prevent metastasis or recurrence. Conventional chemotherapy often causes severe side effects such as myelosuppression and leukopenia. This study aimed to develop a novel nanoparticle-based formulation to improve anticancer efficacy while minimizing toxicity. We synthesized a polymeric micelle formulation incorporating (S)-ibuprofen ((S)-IP) and 2'-hydroxy-2,3,5'-trimethoxychalcone (DK143), termed (S)-IP-DK143 NP.

Identifiers

PMID41768653
PMCPMC12946996

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.