ArticleBiomedical optics express2025
Exploring MPM-FLIM for diagnostics of porokeratosis - a pilot study
Article in Biomedical optics express, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Development of solid-state fluorescence lifetime standards for clinical applications using dyed epoxy resins.Journal of biomedical optics · 2026Article
- Advances in Technology and Applications of Optical Sensing and Imaging for Biomedicine: introduction to the feature issue.Biomedical optics express · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Non-invasive diagnostic methods are essential for early detection and monitoring of skin diseases. This study evaluates multiphoton microscopy with fluorescence lifetime imaging (MPM-FLIM) as a diagnostic tool for porokeratosis. Skin biopsies were analysed using MPM-FLIM at 780 nm excitation wavelength targeting NADH and keratin fluorescence. Key morphological features were identified, such as the presence of cornoid lamella, confirmed by histopathology. Notably, keratin fluorescence (∼1500 ps) was found to dominate in porokeratotic samples, compared to NADH (∼450 ps) in normal skin. These findings support the potential of MPM-FLIM as a valuable diagnostic and research tool for rare skin disorders like porokeratosis.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.