ReviewFrontiers in sports and active living2026
Exercise-specific post-translational modification signatures: unveiling precise regulatory mechanisms of molecular exercise language and cellular adaptation.
Review in Frontiers in sports and active living, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Lactate regulates osteoclastogenesis via H3k18la in osteoarthritis.International journal of molecular medicine · 2026Article
- Cardiac biomarkers in athletes and active individuals: a clinical review of exercise-induced elevations and diagnostic interpretation.Frontiers in physiology · 2026Review
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Authors and funding
8 authors.
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Abstract
Exercise reshapes cellular function and intercellular communication through dynamic post-translational modifications (PTMs) that fine-tune protein activity and inter-organ signaling. However, the traditional aerobic-anaerobic dichotomy does not fully capture PTM-driven regulatory logic across exercise modes. This review centers on the muscle-brain and muscle-liver axes and proposes an operational concept of exercise-specific PTM signatures, emphasizing acetylation, ubiquitination, and lactylation as core PTMs implicated in metabolic memory and adaptive remodeling. To connect exercise intensity with metabolic improvement, we introduce the PTM threshold theory and outline how integrated exercise-PTM-disease target databases, coupled with machine-learning approaches, can support personalized exercise prescription and translation toward exercise pharmacology and rare-disease rehabilitation. Overall, PTM-centered regulatory networks provide a unifying and actionable framework for decoding exercise adaptation and prioritizing therapeutic strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.