ArticleJID innovations : skin science from molecules to population health2026
Dissecting the role of imiquimod and isostearic acid in Aldara-induced psoriasis mouse model.
Article in JID innovations : skin science from molecules to population health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- The multifaceted role of NF-κB signaling in psoriasis: from inflammatory amplification to epidermal remodeling.Frontiers in immunology · 2026Review
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5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aldara (5% imiquimod with 25% isostearic acid [ISA]) cream-induced psoriasiform inflammation is a widely used mouse model to study psoriasis. Imiquimod is a toll-like receptor 7 (TLR7) agonist; however, the role of TLR7 signaling in human psoriasis is unclear. We studied the requirement of TLR7 signaling in Aldara-induced psoriasis and examined the ability of ISA to induce psoriasis in a TLR7-independent manner. C57BL/6J mice were treated with (i) Vaseline, (ii) ISA in Vaseline, (iii) Aldara, (iv) oleic acid in Vaseline, or (v) generic imiquimod formulated with oleic acid. ISA alone did not increase psoriasis-related cytokines or plasmacytoid dendritic cell infiltration into the dorsal skin and failed to induce phenotypic and histological changes of psoriasis. Oleic acid also did not induce significant erythema and scaling, acanthosis, or systemic changes. Imiquimod formulated with either ISA or oleic acid induced psoriasis in vivo. Mechanistically, stimulation of plasmacytoid dendritic cells with ISA did not induce NF-κB activation or inflammatory cytokine expression. Our findings suggest that ISA alone is insufficient to induce psoriasis in vivo or NF-κB-dependent inflammatory cytokines in vitro. This work highlights the critical role of TLR7 signaling in Aldara-induced psoriasis pathogenesis, suggesting that further studies on its direct role in human psoriasis are warranted.
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