Evidence map›Paper›PMID 41769345›Full record

ArticleFrontiers in cellular and infection microbiology2026

Integrative diagnosis of invasive pulmonary aspergillosis in non-neutropenic patients using BALF-tNGS-derived

Furui Liu, Bofei Liu, Jinyan Wang, Zhifeng Wang, Wenyan Zhou, Yonghong Yang, Wenling Chen, Ying Yang, Tao Feng, Jinyuan Zhu

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Research trends in COPD-associated invasive pulmonary aspergillosis over the past two decades: a bibliometric and topic modelling analysis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Review
  2. Beyond detection: quantitative interpretation ofFrontiers in cellular and infection microbiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Furui Liu *The First School of Clinical Medicine, Ningxia Medical University, Yinchuan, Ningxia, China.
Bofei Liu *The First School of Clinical Medicine, Ningxia Medical University, Yinchuan, Ningxia, China.
Jinyan WangThe Fourth People's Hospital of Ningxia Hui Autonomous Region, Yinchuan, Ningxia, China.
Zhifeng WangThe Third People's Hospital of Ningxia, Yinchuan, Ningxia, China.
Wenyan ZhouDepartment of Critical Care Medicine, General Hospital of Ningxia Medical University, Yinchuan, China.
Yonghong YangThe First School of Clinical Medicine, Ningxia Medical University, Yinchuan, Ningxia, China.
Wenling ChenThe First School of Clinical Medicine, Ningxia Medical University, Yinchuan, Ningxia, China.
Ying YangDepartment of Critical Care Medicine, General Hospital of Ningxia Medical University, Yinchuan, China.
Tao FengThe Third People's Hospital of Ningxia, Yinchuan, Ningxia, China.
Jinyuan ZhuDepartment of Critical Care Medicine, General Hospital of Ningxia Medical University, Yinchuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Diagnosing invasive pulmonary aspergillosis (IPA) in non-neutropenic patients is challenging because of non-specific manifestations and limited diagnostic tools. Targeted next-generation sequencing (tNGS) of bronchoalveolar lavage fluid (BALF) enables rapid pathogen detection; however, its capacity for quantitative assessment of fungal load remains unclear. This study integrated BALF-tNGS fungal load with host risk factors to develop a diagnostic nomogram for IPA in non-neutropenic patients. Methods: Non-neutropenic adults with suspected IPA were retrospectively enrolled at three tertiary hospitals (December 2020-December 2024). IPA was classified according to consensus definitions. Normalized Aspergillus reads from BALF-tNGS were stratified into low, medium, and high tiers. Clinical, radiological, and microbiological variables were analyzed, and a multivariable logistic regression model was built and internally validated via bootstrapping. Diagnostic performance was assessed using receiver operating characteristic analysis. Results: Among 238 patients, 134 had IPA and 104 had non-IPA. Compared with non-IPA cases, patients with IPA had higher rates of diabetes (73.9%), corticosteroid exposure (87.3%), bacterial co-infection (94.8%), and intensive care unit (ICU) admission (72.4%) (all Conclusion: Integrating BALF-tNGS-derived normalized

Indexed as

AspergillusBronchoalveolar Lavage FluidHigh-Throughput Nucleotide SequencingInvasive Pulmonary AspergillosisAdultAgedFemaleHumansMaleMiddle AgedRetrospective StudiesRisk FactorsROC Curvebronchoalveolar lavage fluidinvasive pulmonary aspergillosismulticenter studynon-neutropenictargeted next-generation sequencing

Identifiers

PMID41769345
PMCPMC12935974

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.