ArticleCureus2026
Correlation and Prognostic Significance of the Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Score in Acute Ischemic Stroke Survivors.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAcute ischemic stroke (AIS) remains a leading cause of death and long-term disability worldwide. Early identification of high-risk patients is crucial for improving outcomes.
objectiveThis study aimed to determine the correlation and prognostic significance of the Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) score in patients with AIS. METHODOLOGY: This cross-sectional analytical study was conducted at the Liaquat College of Medicine and Dentistry, Karachi, Pakistan, from June 2024 to September 2025. A total of 355 patients diagnosed with AIS were enrolled using non-probability consecutive sampling. Hemoglobin, serum albumin, lymphocyte count, and platelet count were obtained within 24 hours of admission, and the HALP score was calculated as (hemoglobin × albumin × lymphocyte count)/platelet count.
resultsThe mean age of participants was 60.8 ± 11.9 years, with 58.6% males. The mean HALP score was 32.6 ± 16.4. Patients with favorable outcomes (modified Rankin Scale (mRS): 0-2) had significantly higher HALP scores (39.8 ± 14.1) than those with poor outcomes (mRS: 3-6; 22.9 ± 12.6; p < 0.001). HALP was negatively correlated with the National Institutes of Health Stroke Scale (NIHSS) (r = -0.62; p < 0.001) and positively associated with functional independence (r = 0.55; p < 0.001). In multivariate logistic regression, HALP independently predicted poor functional outcome (adjusted odds ratio (OR) = 0.91; 95% CI: 0.87-0.95; p < 0.001) and in-hospital mortality (adjusted OR = 0.89; 95% CI: 0.82-0.96; p = 0.002).
conclusionA lower HALP score is strongly associated with greater stroke severity, worse functional recovery, and higher mortality in patients with AIS.
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