ReviewFrontiers in pharmacology2026
Ferroptosis and cuproptosis in head and neck squamous cell carcinoma: interconnected mechanisms and therapeutic implications.
Review in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Deep Learning for Anticancer Drug Discovery Targeting Non-Apoptotic Regulated Cell Death Mechanisms.Pharmaceuticals (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Head and Neck Squamous Cell Carcinoma (HNSCC) is a highly prevalent malignant neoplasm worldwide. Iron and copper metabolism disorder regulate ferroptosis and cuproptosis, two forms of cell death, respectively, and play key roles in the progression and treatment response of HNSCC. Recent studies have shown that these two death pathways have complex interactions, which together affect the malignant progression and tolerance of HNSCC, providing potential targets for its treatment. This review systematically elucidates the interconnected regulatory networks linking ferroptosis and cuproptosis in HNSCC, with particular emphasis on the clinical significance of associated biomarkers for diagnosis and therapy. We further discuss the potential advantages of dual-targeting strategies and critically evaluate current challenges and limitations in translational applications. By providing novel insights into metal ion-dependent cell death mechanisms, this review establishes a theoretical foundation for developing innovative combinatorial therapeutic approaches against HNSCC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.