Evidence map›Paper›PMID 41770019›Full record

ReviewEpigenomics2026

Targeting epigenetic remodeling of the blood-brain barrier: current knowledge for drug therapy.

Maya Akhoury, Nicole Vegara, Svetlana M Stamatovic, Richard F Keep, Anuska V Andjelkovic

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Epigenomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. The Epigenetic Horizon: New Molecular Perspectives.International journal of molecular sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Maya AkhouryDepartment of Pathology, Neurosurgery and Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Nicole VegaraDepartment of Pathology, Neurosurgery and Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Svetlana M StamatovicDepartment of Pathology, Neurosurgery and Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Richard F KeepDepartment of Pathology, Neurosurgery and Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Anuska V AndjelkovicDepartment of Pathology, Neurosurgery and Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.

Funding

Deciphering the role of junctional adhesion molecule-A in neutrophil-driven inflammatory response in Alzheimer diseaseR01AG084186 · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2025 to 2025
$623k
NIA NIH HHS R01 AG084186
6 · The paper itself

Abstract

The blood - brain barrier (BBB) is a dynamic regulator of brain homeostasis, and its dysfunction is a hallmark of many neurological and psychiatric disorders. Yet, in most conditions, the causal relationship between BBB injury and disease progression remains unclear, as shared systemic risk factors, such as inflammation, infection, oxidative stress, and genetic predisposition, produce highly variable patterns of barrier disruption. Epigenetic mechanisms, including DNA and RNA methylation, histone modifications, chromatin remodeling, and noncoding RNAs, have emerged as key regulators of BBB integrity. Their dysregulation contributes to pathological BBB remodeling in disorders such as cerebrovascular and neurodegenerative diseases, promoting a decline in barrier function (structural and biochemical) and accelerating disease progression. Owing to their reversible nature, epigenetic modifications represent promising therapeutic targets, and their disease-stage-specific patterns offer potential as biomarkers for BBB injury and recovery. This review summarizes current knowledge on how epigenetic processes drive BBB dysfunction and highlights emerging epigenetic signatures with diagnostic and therapeutic relevance across neurological and psychiatric diseases.

Indexed as

Blood-Brain BarrierEpigenesis, GeneticAnimalsChromatin Assembly and DisassemblyDNA MethylationHumansNeurodegenerative DiseasesRNA, UntranslatedRNA, UntranslatedAlzheimer’s diseaseblood-brain barrierDNA methylationhistone modificationRNA methylationstroke

Identifiers

PMID41770019
PMCPMC13097789

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.