Evidence mapPaperPMID 41770028Full record

ReviewFEMS yeast research2026

Engineering yeast for sustainable bioproduction of tryptophan-derived aromatic compounds.

Baode Sun, Xinqi Xie, Axayacatl González, Tim McCubbin, Esteban Marcellin, Huadong Peng

Abstract readReview
In one paragraph

Review in FEMS yeast research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Baode SunUQ Biosustainability Hub, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Queensland 4072, Australia.
Xinqi XieUQ Biosustainability Hub, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Queensland 4072, Australia.
Axayacatl GonzálezUQ Biosustainability Hub, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Queensland 4072, Australia.
Tim McCubbinUQ Biosustainability Hub, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Queensland 4072, Australia.
Esteban MarcellinUQ Biosustainability Hub, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Queensland 4072, Australia.
Huadong PengUQ Biosustainability Hub, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Queensland 4072, Australia.ORCID 0000-0003-0635-0493

Funding

University of Queensland
6 · The paper itself

Abstract

Aromatic compounds are a diverse group of bioactive molecules with broad applications in the polymer, food, feed, cosmetic, and pharmaceutical industries. To address climate change and the depletion of fossil resources, there is growing interest in their sustainable production. Yeast cell factories offer an attractive alternative to conventional chemical synthesis by converting aromatic amino acids (AAAs) into a broad range of valuable aromatic products. Among AAAs, L-tryptophan (Trp) is distinguished by its indole moiety and serves as a key precursor for numerous high-value natural products. This review summarises recent advances in the engineering of yeast to produce tryptophan-derived compounds. Furthermore, it discusses current metabolic engineering strategies, synthetic biology tools, and the remaining challenges that must be overcome to achieve efficient, scalable, and economically viable biosynthesis of tryptophan-derived aromatic compounds in yeast.

Indexed as

Metabolic EngineeringSaccharomyces cerevisiaeTryptophanAmino Acids, AromaticBiological ProductsSynthetic BiologyAmino Acids, AromaticBiological ProductsTryptophanaromatic compoundsL-tryptophanengineering biologysynthetic biologyyeast cell factory

Identifiers

PMID41770028
PMCPMC13001592

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.