Evidence mapPaperPMID 41770413Full record

ReviewAmerican journal of physiology. Cell physiology2026

Interstitial cells and arrhythmia.

Eva A Rog-Zielinska, Jana Grune, Thorsten Kessler, Achim Lother, Peter Kohl

Abstract readReview
In one paragraph

Review in American journal of physiology. Cell physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Eva A Rog-ZielinskaInstitute for Experimental Cardiovascular Medicine, University Heart Center and Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID 0000-0002-3295-4728
Jana GruneDepartment of Cardiothoracic and Vascular Surgery, German Heart Center Berlin at Charité, Berlin, Germany.ORCID 0000-0001-6209-7416
Thorsten KesslerDepartment of Cardiology, German Heart Centre, TUM University Hospital, Munich, Germany.ORCID 0000-0003-3326-1621
Achim LotherInstitute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID 0000-0001-9107-5558
Peter KohlInstitute for Experimental Cardiovascular Medicine, University Heart Center and Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID 0000-0003-0416-6270

Funding

Corona-Stiftung (Corona Foundation) S199/10070/2017Corona-Stiftung (Corona Foundation) S199/10086/2022Deutsche Forschungsgemeinschaft (DFG) GR 5261/5-1Deutsche Forschungsgemeinschaft (DFG) SFB 1123Deutsche Forschungsgemeinschaft (DFG) SFB1425EC | European Research Council (ERC) 101077205
6 · The paper itself

Abstract

The electrophysiological relevance of interstitial nonmyocytes for cardiac electrophysiology arises from their abundant direct and indirect interactions with cardiac myocytes. This review defines the interstitium, explores biophysical and biochemical mechanisms of interactions between interstitial components and cardiac myocytes, illustrates consequences of these interactions for heart rhythm, and identifies targets for further research in this area.

Indexed as

Arrhythmias, CardiacMyocardiumMyocytes, CardiacAction PotentialsAnimalsCell CommunicationHumansarrhythmiafibrosisheartheterocellular couplinginterstitium

Identifiers

PMID41770413
PMCPMC7618984

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.