Evidence map›Paper›PMID 41770504›Full record

ArticleAnnals of nuclear medicine2026

Semi-quantitative tau PET approaches for Braak staging: concordance of CenTauRz and STOC with visual assessment.

Kaito Wachi, Tensho Yamao, Kenta Miwa, Noriaki Miyaji, Naochika Akiya, Takuma Horikawa, Masaki Masubuchi, Shu Kimura, Hiroshi Matsuda

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Article in Annals of nuclear medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

9 authors.

Kaito WachiDepartment of Radiological Sciences, Graduate School of Health Sciences, Fukushima Medical University, 10-6 Sakaemachi, Fukushima-Shi, Fukushima, 960-8516, Japan.
Tensho YamaoDepartment of Radiological Sciences, School of Health Sciences, Fukushima Medical University, 10-6 Sakaemachi, Fukushima-Shi, Fukushima, 960-8516, Japan.
Kenta MiwaDepartment of Radiological Sciences, Graduate School of Health Sciences, Fukushima Medical University, 10-6 Sakaemachi, Fukushima-Shi, Fukushima, 960-8516, Japan. kenta5710@gmail.com.ORCID http://orcid.org/0000-0003-0802-0180
Noriaki MiyajiDepartment of Radiological Sciences, School of Health Sciences, Fukushima Medical University, 10-6 Sakaemachi, Fukushima-Shi, Fukushima, 960-8516, Japan.
Naochika AkiyaDepartment of Radiological Sciences, Graduate School of Health Sciences, Fukushima Medical University, 10-6 Sakaemachi, Fukushima-Shi, Fukushima, 960-8516, Japan.
Takuma HorikawaDepartment of Radiological Sciences, School of Health Sciences, Fukushima Medical University, 10-6 Sakaemachi, Fukushima-Shi, Fukushima, 960-8516, Japan.
Masaki MasubuchiDepartment of Radiological Sciences, Graduate School of Health Sciences, Fukushima Medical University, 10-6 Sakaemachi, Fukushima-Shi, Fukushima, 960-8516, Japan.
Shu KimuraDepartment of Radiological Sciences, School of Health Sciences, Fukushima Medical University, 10-6 Sakaemachi, Fukushima-Shi, Fukushima, 960-8516, Japan.
Hiroshi MatsudaNippon Medical School, Clinical Imaging Center for Healthcare, 1-12-15 Sendagi, Bunkyoku, Tokyo, 113-0022, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe progression of tau pathology in Alzheimer's disease (AD) is closely linked to cognitive decline. Visual Braak staging of tau PET reflects neurofibrillary tangle distribution but requires expertise in interpretation. The present study aimed to evaluate agreement between Braak stages and semi-quantitative CenTauRz and Simplified Temporal-Occipital Classification (STOC).

methodsWe collected data from 112 persons with normal cognition (NC), as well as 103 patients with mild cognitive impairment (MCI), and 48 with AD who were assessed by

resultsThe accuracy of CenTauRz compared to Braak stages was 0.84-0.90, κ = 0.61-0.77, and ρ = 0.67-0.83 and that of STOC was 0.87; κ = 0.71, and ρ = 0.81. CenTauRz captured the regional heterogeneity of tau accumulation, whereas STOC provided a staging framework aligned with Braak progression.

conclusionThe agreement of CenTauRz and STOC with visually assessed Braak stages was strong. Combinations of semi-quantitative methods might serve as complementary tools for tau PET images and improve interpretive reliability and objectivity.

Indexed as

Alzheimer DiseaseImage Processing, Computer-AssistedPositron-Emission Tomographytau ProteinsAgedAged, 80 and overCognitive DysfunctionFemaleHumansMaletau Proteins18F-flortaucipirAlzheimer’s diseaseBraak stagingCenTauRzSTOCTau PET

Identifiers

PMID41770504

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.