Evidence mapPaperPMID 41770536Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2026

Morning endurance training induces superior performance adaptations compared with afternoon training in mice.

Stuart J Hesketh, Collin M Douglas, Xiping Zhang, Christopher A Wolff, Casey L Sexton, Elizabeth S Nowicki, Karyn A Esser

Abstract readComparative Study
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Stuart J HeskethDepartment of Physiology and Aging, University of Florida, Gainesville, Florida, United States.ORCID 0000-0001-7855-2380
Collin M DouglasDepartment of Physiology and Aging, University of Florida, Gainesville, Florida, United States.ORCID 0000-0002-7601-3508
Xiping ZhangDepartment of Physiology and Aging, University of Florida, Gainesville, Florida, United States.ORCID 0000-0003-3202-451X
Christopher A WolffDepartment of Physiology and Aging, University of Florida, Gainesville, Florida, United States.
Casey L SextonDepartment of Physiology and Aging, University of Florida, Gainesville, Florida, United States.ORCID 0009-0003-4852-4153
Elizabeth S NowickiDepartment of Physiology and Aging, University of Florida, Gainesville, Florida, United States.
Karyn A EsserDepartment of Physiology and Aging, University of Florida, Gainesville, Florida, United States.ORCID 0000-0002-5791-1441

Funding

UF PASS: Regulation of exercise transducersU01AG055137 · NIA · UNIVERSITY OF FLORIDA · PI Karyn A Esser · 2022 to 2022
$800k
Circadian Clock and Muscle HealthR01AR079220 · UNIVERSITY OF FLORIDA · 2025 to 2025
$440k
HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) R01AR079220HHS | NIH | National Institute on Aging (NIA) U01AG055137NIAMS NIH HHS R01 AR079220NIA NIH HHS U01 AG055137Wu Tsai Human Performance Alliance AGR00023600
6 · The paper itself

Abstract

Endurance performance exhibits time-of-day variation in both humans and rodents, peaking in the late-active phase. However, whether the timing of endurance training influences performance adaptations remains unclear. To investigate, female mice were trained 5 days/wk for 6 wk at either ZT13 or ZT22, using treadmill running at 70% of each animal's maximal capacity. Endurance performance was assessed at baseline,

Indexed as

Adaptation, PhysiologicalCircadian RhythmEndurance TrainingPhysical Conditioning, AnimalPhysical EnduranceAnimalsBlood GlucoseBody CompositionFemaleGlycogenLactic AcidLiverMiceMice, Inbred C57BLMuscle, SkeletalTime FactorsBlood GlucoseGlycogenLactic Acidcircadian rhythmexercise timingexercise trainingmitochondrial adaptationskeletal muscle

Identifiers

PMID41770536
PMCPMC13022755

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.